beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking.
beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking.
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DOI：
10.1001/archgenpsychiatry.2009.41
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发表时间：
2009-06
影响因子：
--
通讯作者：
Staley, Julie K.
中科院分区：
文献类型：
--
作者：
Cosgrove, Kelly P.;Batis, Jeffery;Bois, Frederic;Maciejewski, Paul K.;Esterlis, Irina;Kloczynski, Tracy;Stiklus, Stephanie;Krishnan-Sarin, Suchitra;O'Malley, Stephanie;Perry, Edward;Tamagnan, Gilles;Seibyl, John P.;Staley, Julie K.
与从不吸烟者相比，最近戒烟者的β2*-烟碱乙酰胆碱受体（β2*-nAChR）可用性更高。戒烟过程中β2*-nAChR可用性的变化可能与吸烟冲动、尼古丁戒断程度和成功戒烟有关。研究急性和长期戒烟期间β2*-nAChR可用性的变化，并确定β2*-nAChR可用性的变化如何与吸烟的临床特征相关。吸烟者在戒烟期间参与了多达4次[123 I]5-IA-85380（[123 I]5-IA）单光子发射计算机断层扫描（SPECT）：1天（n=7）、1周（n=17）、2周（n=7）、4周（n=11）和6-12周（n=6）。匹配的非吸烟者参加了1次[123 I]5-IA SPECT扫描。所有受试者均完成了1项磁共振成像研究。学术影像中心。吸烟者（n=19）和年龄匹配的非吸烟者对照组（n=20）。将[123 I]5-IA SPECT图像转换为分布体积，并使用感兴趣区域进行分析。与不吸烟者相比，戒烟1 d时吸烟者纹状体、皮质和小脑β2*-nAChR的利用率无显著性差异，戒烟1周时显著高于不吸烟者，戒烟4周或6-12周时无显著性差异。在吸烟者中，戒烟6-12周时，皮质和小脑中的β2*-nAChR可用性显著低于戒烟1周。此外，戒断4周时小脑β2*-nAChR的可用性与扫描当天的渴望呈正相关。这些数据表明，较高的β2*-nAChR可用性持续戒烟1个月，并在戒烟6-12周后恢复至非吸烟者水平。β2*-nAChR可用性的这些显著和持续变化可能导致戒烟困难。
β2*-nicotinic acetylcholine receptor (β2*-nAChR) availability is higher in recently abstinent smokers compared to never smokers. Variations in β2*-nAChR availability over the course of abstinence may be related to the urge to smoke, the extent of nicotine withdrawal and successful abstinence. To examine changes in β2*-nAChR availability during acute and prolonged abstinence from tobacco smoking and to determine how changes in β2*-nAChR availability were related to clinical features of tobacco smoking. Tobacco smokers participated in up to 4 [123I]5-IA-85380 ([123I]5-IA) single photon emission computed tomography (SPECT) scans during abstinence: 1 day (n=7), 1 week (n=17), 2 weeks (n=7), 4 weeks (n=11), and 6-12 weeks (n=6). Age-matched nonsmokers participated in 1 [123I]5-IA SPECT scan. All subjects completed 1 magnetic resonance imaging study. Academic imaging center. Tobacco smokers (n=19) and an age-matched nonsmoker comparison group (n=20). [123I]5-IA SPECT images were converted to distribution volume and were analyzed using regions of interest. Compared to nonsmokers, β2*-nAChR availability in the striatum, cortex and cerebellum of smokers was not different at one day of abstinence, significantly higher at 1week of abstinence and not different at 4 or 6-12 weeks of abstinence. In smokers, at 6-12 weeks of abstinence, β2*-nAChR availability was significantly lower in the cortex and cerebellum compared to 1 week of abstinence. Additionally, cerebellar β2*-nAChR availability at 4 weeks of abstinence was positively correlated with craving on the day of scan. These data suggest higher β2*-nAChR availability persists up to 1 month of abstinence, and normalizes to nonsmoker levels by 6-12 weeks of abstinence from tobacco smoking. These marked and persistent changes in β2*-nAChR availability may contribute to difficulties with tobacco cessation.
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