Genomic analysis of the causative agents of coccidiosis in domestic chickens.
Genomic analysis of the causative agents of coccidiosis in domestic chickens.
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家用鸡的球虫病的致病药物的基因组分析。
DOI：
10.1101/gr.168955.113
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发表时间：
2014-10
期刊：
影响因子：
7
通讯作者：
Pain A
中科院分区：
文献类型：
--
作者：
Reid AJ;Blake DP;Ansari HR;Billington K;Browne HP;Bryant J;Dunn M;Hung SS;Kawahara F;Miranda-Saavedra D;Malas TB;Mourier T;Naghra H;Nair M;Otto TD;Rawlings ND;Rivailler P;Sanchez-Flores A;Sanders M;Subramaniam C;Tay YL;Woo Y;Wu X;Barrell B;Dear PH;Doerig C;Gruber A;Ivens AC;Parkinson J;Rajandream MA;Shirley MW;Wan KL;Berriman M;Tomley FM;Pain A
在过去的二十年里，全球鸡的产量增加了两倍，它们现在是全球最重要的膳食动物蛋白来源。鸡容易受到许多传染病的影响，这些疾病会降低它们的性能和生产力。球虫病是由艾美耳球虫属（Eimeria）顶复门原虫引起的一种重要的家禽疾病。了解艾美耳球虫寄生虫的生物学有助于开发改善全球粮食安全所需的新药和疫苗。我们已经产生了所有七种艾美耳球虫感染家鸡，揭示了以前描述的重复丰富和重复穷人的地区的全部范围内的注释基因组序列，并显示这些寄生虫拥有最重复丰富的蛋白质组有史以来描述。此外，虽然没有其他apicomplexan已被发现拥有逆转录转座子，艾美耳球虫是一个家庭的彩色病毒。艾美球虫基因参与基础生物学和宿主-寄生虫相互作用的分析突出了适应相对简单的发育生命周期和复杂的阵列的共表达的表面蛋白参与宿主细胞结合。
Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.
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影响因子：
6.7
作者：
Blake DP;Billington KJ;Copestake SL;Oakes RD;Quail MA;Wan KL;Shirley MW;Smith AL
通讯作者：
Smith AL
影响因子：
6.7
作者：
Campbell TL;De Silva EK;Olszewski KL;Elemento O;Llinás M
通讯作者：
Llinás M
影响因子：
2.9
作者：
Anamika;Srinivasan, N;Krupa, A
通讯作者：
Krupa, A
影响因子：
4.1
作者：
Kueck, Patrick;Meusemann, Karen
通讯作者：
Meusemann, Karen
影响因子：
14.9
作者：
Balaji S;Babu MM;Iyer LM;Aravind L
通讯作者：
Aravind L