Complete Blood Cell Count-Derived Inflammatory Biomarkers in Early-Stage Non-Small-Cell Lung Cancer.
Complete Blood Cell Count-Derived Inflammatory Biomarkers in Early-Stage Non-Small-Cell Lung Cancer.
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DOI：
10.5761/atcs.oa.19-00315
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发表时间：
2020-10-21
期刊：
影响因子：
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通讯作者：
Takeo S
中科院分区：
文献类型：
--
作者：
Shoji F;Kozuma Y;Toyokawa G;Yamazaki K;Takeo S
背景资料：全血细胞计数（CBC）衍生的炎症生物标志物被广泛用作各种恶性肿瘤的预后参数，但早期非小细胞肺癌（NSCLC）的最佳预测生物标志物尚不清楚。我们回顾性分析了早期NSCLC患者，以研究术前CBC衍生的炎症生物标志物的预测作用。患者和方法：我们选择了2006年4月至2012年12月期间手术切除的311例病理IA期非小细胞肺癌患者。采用单因素和多因素考克斯比例分析法对术前全身免疫炎症指数（SII）、嗜中性粒细胞-淋巴细胞比率（NLR）、血小板-淋巴细胞比率（PLR）和单核细胞-淋巴细胞比率（MLR）进行分析。结果如下：术前高MLR水平与患者性别、吸烟状况和术后复发显著相关（分别为p <0.0001、p = 0.0307和p = 0.0146），术前高SII水平与术后复发显著相关（p = 0.0458）。NLR和PLR均与任何相关因素无关。只有术前MLR水平（p = 0.0269）被确定为较短RFS的独立预测因素。术前高MLR水平与低水平患者的相对风险（RR）为2.259（95%置信区间[CI]：1.094-5.000）。术前MLR水平高的患者的5年RFS率显著低于MLR水平低的患者（82.21% vs. 92.05%，p = 0.0062）。在肿瘤大小和MLR水平的亚组分析中，肿瘤>2 cm的高MLR水平亚组的RFS显著短于其他亚组（p = 0.0289）。结论：术前MLR水平是预测IA期NSCLC复发的最佳指标。
Background: Complete blood cell count (CBC)-derived inflammatory biomarkers are widely used as prognostic parameters for various malignancies, but the best predictive biomarker for early-stage non-small-cell lung cancer (NSCLC) is unclear. We retrospectively analyzed early-stage NSCLC patients to investigate predictive effects of preoperative CBC-derived inflammatory biomarkers. Patients and Methods: We selected 311 consecutive patients with pathological stage IA NSCLC surgically resected from April 2006 to December 2012. Univariate and multivariate Cox proportional analyses of recurrence-free survival (RFS) were used to test the preoperative systemic immune inflammation index (SII), neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and monocyte–lymphocyte ratio (MLR). Results: Preoperative high MLR levels were significantly associated with patient sex, smoking status, and postoperative recurrence (p <0.0001, p = 0.0307, and p = 0.0146, respectively), and preoperative high SII levels were significantly correlated with postoperative recurrence (p = 0.0458). Neither NLR nor PLR were associated with any related factors. Only preoperative MLR levels (p = 0.0269) were identified as an independent predictor of shorter RFS. The relative risk (RR) for preoperative high MLR level versus low level patients was 2.259 (95% confidence interval [CI]: 1.094–5.000). Five-year RFS rates in patients with preoperatively high MLR levels were significantly lower than in those with low MLR levels (82.21% vs. 92.05%, p = 0.0062). In subgroup analysis by tumor size and MLR level, the high MLR level subgroup with tumors >2 cm had significantly shorter RFS than other subgroups (p = 0.0289). Conclusions: The preoperative MLR level is the optimal predictor of recurrence in patients with pathological stage IA NSCLC.
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中性粒细胞与淋巴细胞比率和单核细胞与淋巴细胞比率升高以及血小板与淋巴细胞比率降低与多发性骨髓瘤的不良预后相关。
影响因子：
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作者：
Shi L;Qin X;Wang H;Xia Y;Li Y;Chen X;Shang L;Tai YT;Feng X;Acharya P;Acharya C;Xu Y;Deng S;Hao M;Zou D;Zhao Y;Ru K;Qiu L;An G
通讯作者：
An G
DOI：
10.1038/nrclinonc.2016.217
发表时间：
2017-07
期刊：
Nature reviews. Clinical oncology
影响因子：
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作者：
Mantovani A;Marchesi F;Malesci A;Laghi L;Allavena P
通讯作者：
Allavena P
影响因子：
6.2
作者：
Varlotto, John M.;Recht, Abram;DeCamp, Malcolm M.
通讯作者：
DeCamp, Malcolm M.
影响因子：
5.3
作者：
Shoji, Fumihiro;Morodomi, Yosuke;Maehara, Yoshihiko
通讯作者：
Maehara, Yoshihiko
影响因子：
20.4
作者：
Goldstraw, Peter;Chansky, Kari;Bolejack, Vanessa
通讯作者：
Bolejack, Vanessa