T Helper Cell Differentiation, Heterogeneity, and Plasticity.
T Helper Cell Differentiation, Heterogeneity, and Plasticity.
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DOI：
10.1101/cshperspect.a030338
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发表时间：
2018-10-01
影响因子：
7.2
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Zhu J
幼稚的CD4T细胞在激活后分化为不同的辅助性T细胞(Th)亚群，产生谱系特异性细胞因子。通过产生一组独特的细胞因子，效应器Th亚群在协调对各种感染的免疫反应中发挥关键作用，并参与许多炎症性疾病的发病机制，包括自身免疫、过敏和哮喘。Th细胞的分化依赖于T细胞受体(TCR)信号的强度，以及由激活和/或上调特定转录因子的极化细胞因子触发的信号。几个谱系特异的主要转录因子决定了Th细胞的命运和功能。尽管这些主要监管机构相互交叉监管，但它们的表达可能是动态的。有时，它们甚至共表达，导致大量Th细胞的异质性和可塑性。在作为Th细胞的先天对应的先天淋巴样细胞(ILCs)中，也发现了由这些主要调节因子介导的类似调控。
Naïve CD4 T cells, on activation, differentiate into distinct T helper (Th) subsets that produce lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play critical roles in orchestrating immune responses to a variety of infections and are involved in the pathogenesis of many inflammatory diseases including autoimmunity, allergy, and asthma. The differentiation of Th cells relies on the strength of T-cell receptor (TCR) signaling and signals triggered by polarizing cytokines that activate and/or up-regulate particular transcription factors. Several lineage-specific master transcription factors dictate Th cell fates and functions. Although these master regulators cross-regulate each other, their expression can be dynamic. Sometimes, they are even coexpressed, resulting in massive Th-cell heterogeneity and plasticity. Similar regulation mediated by these master regulators is also found in innate lymphoid cells (ILCs) that are innate counterparts of Th cells.
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DOI：
10.4049/jimmunol.1300379
发表时间：
2013-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Furusawa J;Moro K;Motomura Y;Okamoto K;Zhu J;Takayanagi H;Kubo M;Koyasu S
通讯作者：
Koyasu S
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
14.2
作者：
Cosmi, Lorenzo;Maggi, Laura;Annunziato, Francesco
通讯作者：
Annunziato, Francesco
影响因子：
56.9
作者：
COFFMAN, RL;SEYMOUR, BWP;RENNICK, D
通讯作者：
RENNICK, D
影响因子：
30.5
作者：
Afkarian, M;Sedy, JR;Murphy, KM
通讯作者：
Murphy, KM