Cardiovascular risk factors and illicit drug use may have a more profound effect on coronary atherosclerosis progression in people living with HIV.
Cardiovascular risk factors and illicit drug use may have a more profound effect on coronary atherosclerosis progression in people living with HIV.
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DOI：
10.1007/s00330-021-07755-7
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发表时间：
2021-05
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
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在非裔美国人的纵向研究中评估HIV感染是否直接或间接促进冠状动脉疾病（CAD）体积进展。我们从2004年5月至2015年8月的前瞻性流行病学研究的1429名心血管无症状参与者中随机选择了300名亚临床CAD患者（210名男性;年龄：48.0±7.2岁; 226名HIV感染者，174名可卡因使用者）。个体在两个时间点接受冠状动脉CT血管造影（平均随访：4.0±2.3年）。我们量化了非钙化（NCP：-100-350HU）、低衰减非钙化（LA-NCP：-100-30HU）和钙化（CP：≥ 351 HU）斑块体积。采用线性混合模型评估HIV感染、动脉粥样硬化性心血管疾病（ASCVD）风险、可卡因使用年限对斑块体积的影响。HIV感染者和未感染者之间的NCP年进展率无显著差异（8.65 [IQR：2.97-19.42] mm 3/年vs. 4.85 [IQR：1.50-18.26] mm 3/年，p=0.14），LA-NCP（0.24 [IQR：0.00-1.61] mm 3/年vs. 0.15 [IQR：0.00-0.91] mm 3/年，p=0.07）或CP体积（0.27 [IQR：0.00-3.38] mm 3/年vs. 0.05 [IQR：0.00-3.22] mm 3/年，p=0.30）。多变量分析显示，HIV感染与NCP（−6.9mm3，CI：[−32.8-19.0]，p=0.60）、LA-NCP（−0.1mm3，CI：[−2.6-2.4]，p=0.92）或CP体积（−0.3mm3，CI：[−9.3-8.6]，p=0.96）无关。然而，ASCVD的每一个百分比和可卡因的每年使用显着增加艾滋病毒感染者的总，NCP和CP体积，但不是在艾滋病毒未感染者。重要的是，没有一种HIV相关药物对斑块体积有任何影响（p>0.05）。HIV感染者中危险因素的更深刻的不良影响可能解释了这些人CAD的加速进展，因为HIV感染与任何冠状动脉斑块体积无关。
To assess whether HIV-infection directly or indirectly promotes coronary artery disease (CAD) volume progression in a longitudinal study of African Americans. We randomly selected 300 individuals with subclinical CAD (210 male; age: 48.0±7.2 years; 226 HIV-infected, 174 cocaine-users) from 1429 cardiovascularly asymptomatic participants of a prospective epidemiological study between May 2004 and August 2015. Individuals underwent coronary CT angiography at two time points (mean follow-up: 4.0±2.3 years). We quantified noncalcified (NCP: −100–350HU), low-attenuation noncalcified (LA-NCP: −100–30HU) and calcified (CP: ≥351HU) plaque volumes. Linear mixed models were used to assess the effects of HIV-infection, atherosclerotic cardiovascular disease (ASCVD) risk, years of cocaine use on plaque volumes. There was no significant difference in annual progression rates between HIV-infected and -uninfected regarding NCP (8.65 [IQR: 2.97–19.42]mm3/year vs. 4.85 [IQR: 1.50–18.26]mm3/year, p=0.14), LA-NCP (0.24 [IQR: 0.00–1.61]mm3/year vs. 0.15 [IQR: 0.00–0.91]mm3/year, p=0.07) or CP volumes (0.27 [IQR: 0.00–3.38]mm3/year vs. 0.05 [IQR: 0.00–3.22]mm3/year, p=0.30). Multivariately, HIV-infection was not associated with NCP (−6.9mm3, CI: [−32.8–19.0], p=0.60), LA-NCP (−0.1mm3, CI: [−2.6–2.4], p=0.92) or CP volumes (−0.3mm3, CI: [−9.3–8.6], p=0.96). However, each percentage of ASCVD and each year of cocaine use significantly increased total, NCP and CP volumes among HIV-infected individuals, but not among HIV-uninfected. Importantly, none of the HIV-associated medications had any effect on plaque volumes (p>0.05 for all). The more profound adverse effect of risk factors in HIV-infected individuals may explain the accelerated progression of CAD in these people, as HIV-infection was not independently associated with any coronary plaque volume.
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影响因子：
24
作者：
Chang HJ;Lin FY;Lee SE;Andreini D;Bax J;Cademartiri F;Chinnaiyan K;Chow BJW;Conte E;Cury RC;Feuchtner G;Hadamitzky M;Kim YJ;Leipsic J;Maffei E;Marques H;Plank F;Pontone G;Raff GL;van Rosendael AR;Villines TC;Weirich HG;Al'Aref SJ;Baskaran L;Cho I;Danad I;Han D;Heo R;Lee JH;Rivzi A;Stuijfzand WJ;Gransar H;Lu Y;Sung JM;Park HB;Berman DS;Budoff MJ;Samady H;Shaw LJ;Stone PH;Virmani R;Narula J;Min JK
通讯作者：
Min JK
影响因子：
4.8
作者：
Grinspoon, Steven K.;Fitch, Kathleen V.;Douglas, Pamela S.
通讯作者：
Douglas, Pamela S.
影响因子：
37.8
作者：
Fleg, JL;Morrell, CH;Lakatta, EG
通讯作者：
Lakatta, EG
影响因子：
158.5
作者：
Huetter, Gero;Nowak, Daniel;Thiel, Eckhard
通讯作者：
Thiel, Eckhard
DOI：
10.1016/s2352-3018(14)00032-0
发表时间：
2015-02
期刊：
The lancet. HIV
影响因子：
--
作者：
Lo J;Lu MT;Ihenachor EJ;Wei J;Looby SE;Fitch KV;Oh J;Zimmerman CO;Hwang J;Abbara S;Plutzky J;Robbins G;Tawakol A;Hoffmann U;Grinspoon SK
通讯作者：
Grinspoon SK