Somatosensory scaffolding structures.

Somatosensory scaffolding structures.
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DOI:
10.3389/fnmol.2012.00002
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发表时间:
2012
影响因子:
4.8
通讯作者:
Jeske NA
Jeske NA
中科院分区:
医学2区
文献类型:
--
作者:
Jeske NA

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体感感知的动态变化是多个信号事件的结果。在许多情况下,感觉受体的过度激活导致脱敏和随后增加的受体激活阈值。在其他情况下,受体敏化可在组织损伤和/或炎症后发生。在这两种情况下,控制受体活性改变的信号机制可以显著影响生物体对感觉刺激的反应,包括热,机械和化学刺激。由于躯体感觉识别的稳态性质,受体反应的动态变化可能对个体的生活方式产生负面影响,并提醒个体注意组织损伤。在这里,我们将集中在调节躯体感觉神经元兴奋性的支架结构。
Dynamic changes in somatosensory perception occur as a result of multiple signaling events. In many instances, over-activation of sensory receptors results in the desensitization and subsequent increased threshold for activation of receptors. In other cases, receptor sensitization can occur following tissue injury and/or inflammation. In both cases, signaling mechanisms that control alterations in receptor activities can significantly affect organism response to sensory stimuli, including thermal, mechanical, and chemical. Due to the homeostatic nature of somatosensory recognition, dynamic changes in receptor response can negatively affect an individual's way of life, as well as alert individuals to tissue damage. Here, we will focus on scaffolding structures that regulate somatosensory neuronal excitability.
线粒体活性氧通过 IP3 被 mGluR5 激活,并激活 ERK 和 PKA,从而增加杏仁核神经元的兴奋性和疼痛行为。
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