Evolutionary history of the vertebrate mitogen activated protein kinases family.
Evolutionary history of the vertebrate mitogen activated protein kinases family.
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DOI：
10.1371/journal.pone.0026999
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Li M;Liu J;Zhang C
有丝分裂原活化蛋白激酶（MAPK）家族途径涉及大多数生物体必需的多种细胞过程和途径。它的进化在整个真核生物王国中都是保守的。然而，脊椎动物MAPK家族的详细进化史在很大程度上是不清楚的。MAPK家族成员是通过文献或以已知的MAPK序列为查询，通过检索几种脊椎动物和无脊椎动物的基因组收集的。我们发现脊椎动物的MAPK家族成员明显多于无脊椎动物，并且脊椎动物的MAPK家族起源于3个祖先，这表明在脊椎动物与无脊椎动物分化之后发生了一次基因复制事件的爆发。在脊椎动物MAPK亚家族4、6、7和11至14中观察到进化同源性的保守性。基于同源性和系统发育关系，MAPK12似乎是由MAPK11的串联重复产生的，MAPK13-MAPK14基因单元是由MAPK11-MAPK12基因单元的片段重复产生的。适应性进化分析表明，纯化选择驱动了MAPK家族的进化，这表明MAPK基因具有很强的功能约束。有趣的是，在从硬骨鱼到两栖动物和哺乳动物的进化过程中，在MAPK4和MAPK7基因中特别观察到内含子丢失，而在它们的侧翼基因中则没有。内含子丢失在MAPK4和MAPK7亚家族中的特异性发生可能与脊椎动物的适应性进化有关，这两种MAPK基因的表达水平均有所提高。这些结果为了解脊椎动物MAPK家族的进化史提供了有价值的见解。
The mitogen activated protein kinases (MAPK) family pathway is implicated in diverse cellular processes and pathways essential to most organisms. Its evolution is conserved throughout the eukaryotic kingdoms. However, the detailed evolutionary history of the vertebrate MAPK family is largely unclear. The MAPK family members were collected from literatures or by searching the genomes of several vertebrates and invertebrates with the known MAPK sequences as queries. We found that vertebrates had significantly more MAPK family members than invertebrates, and the vertebrate MAPK family originated from 3 progenitors, suggesting that a burst of gene duplication events had occurred after the divergence of vertebrates from invertebrates. Conservation of evolutionary synteny was observed in the vertebrate MAPK subfamilies 4, 6, 7, and 11 to 14. Based on synteny and phylogenetic relationships, MAPK12 appeared to have arisen from a tandem duplication of MAPK11 and the MAPK13-MAPK14 gene unit was from a segmental duplication of the MAPK11-MAPK12 gene unit. Adaptive evolution analyses reveal that purifying selection drove the evolution of MAPK family, implying strong functional constraints of MAPK genes. Intriguingly, however, intron losses were specifically observed in the MAPK4 and MAPK7 genes, but not in their flanking genes, during the evolution from teleosts to amphibians and mammals. The specific occurrence of intron losses in the MAPK4 and MAPK7 subfamilies might be associated with adaptive evolution of the vertebrates by enhancing the gene expression level of both MAPK genes. These results provide valuable insight into the evolutionary history of the vertebrate MAPK family.
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影响因子：
3.4
作者：
Kawaguchi M;Hiroi J;Miya M;Nishida M;Iuchi I;Yasumasu S
通讯作者：
Yasumasu S
影响因子：
4.4
作者：
Krens SF;Corredor-Adámez M;He S;Snaar-Jagalska BE;Spaink HP
通讯作者：
Spaink HP
影响因子：
4.1
作者：
Almog, Tal;Naor, Zvi
通讯作者：
Naor, Zvi
DOI：
10.1007/s00534-009-0155-x
发表时间：
2009-11-01
期刊：
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY
影响因子：
--
作者：
King, LaShonda A.;Toledo, Alexander H.;Toledo-Pereyra, Luis H.
通讯作者：
Toledo-Pereyra, Luis H.
影响因子：
4.8
作者：
Abe, MK;Saelzler, MP;Rosner, MR
通讯作者：
Rosner, MR