Role of nitric oxide in lower esophageal sphincter relaxation to swallowing.
Role of nitric oxide in lower esophageal sphincter relaxation to swallowing.
复制标题
一氧化氮在下食管括约肌松弛吞咽中的作用。
DOI：
10.1016/0024-3205(92)90326-k
复制
发表时间：
1992
期刊：
影响因子：
6.1
通讯作者：
Goyal,RK
中科院分区：
文献类型：
--
作者：
Yamato,S;Saha,JK;Goyal,RK
Studies were performed in the opossum to define the role of the L-arginine-nitric oxide (NO) pathway in lower esophageal sphincter (LES) relaxation to swallowing and vagal stimulation in vivo and intramural nerve stimulationin vitro. In vivo, L-NAME, a water soluble NO synthase (NOS) inhibitor, caused antagonism of LES relaxation due to reflex-induced swallowing. L-NAME (20 mg/kg i.v.) reduced the amplitude of swallow induced relaxation from 88% to 28%. LES relaxation due to electrical stimulation of peripheral end of decentralized vagus nerve was also antagonized. The effects of L-NAME were reversed by L-arginine, but not by D-arginine. L-NAME treatment did not antagonize LES relaxation to intravenous administration of isoproterenol.In vitro, NO and sodium nitroprusside (SNP) caused a decrease in the sphincter tone. The relaxing effect caused by NO and SNP was not antagonized by tetrodotoxin or omega-conotoxin. Inhibitors of NO synthase, L-NMMA and L-NNA, caused slight increase in the spontaneous resting LES tone and concentration-dependent antagonism of electrical field stimulation (EFS) induced LES relaxation. L-NNA (10−4M) abolished EFS induced LES relaxation at low frequencies (<5 Hz) and antagonized the relaxation to a L-NNA was unaffected by D-arginine but was reversed by L-arginine. The inhibitory effect of NO, SNP, or two other putative inhibitory neurotransmitters (VIP and CGRP) on the LES was not antagonized by L-NNA. These studies show that inhibitors of NO synthase selectively antagonize LES relaxation to all three modes of intramural inhibitory nerve stimulation including physiological swallowing. These studies suggest that the L-arginine-nitric oxide pathway is involved in physiological relaxation of the LES.
登录
查看更多内容
影响因子：
--
作者：
J. Christensen;J. Conklin;B. Freeman
通讯作者：
B. Freeman
DOI：
10.1007/978-88-470-1405-3_42
发表时间：
2012
期刊：
--
影响因子：
--
作者：
Arieh Riskin;Carlo Agostoni;R. Shamir
通讯作者：
Arieh Riskin;Carlo Agostoni;R. Shamir
神经递质身份怀疑
影响因子：
64.8
作者：
L. Ignarro;P. A. Bush;G. Buga;J. Rajfer
通讯作者：
J. Rajfer
NG-monomethyl L-arginine 是一种非特异性血管舒张抑制剂。
影响因子：
5
作者：
Thomas,G;Cole,EA;Ramwell,PW
通讯作者：
Ramwell,PW
基础括约肌压力的起源：河豚毒素对负鼠体内下食管括约肌压力的影响。
影响因子：
29.4
作者：
Raj K. Goyal;Satish Rattan
通讯作者：
Satish Rattan