Macro view of microRNA function in osteoarthritis.
Macro view of microRNA function in osteoarthritis.
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DOI：
10.1038/nrrheum.2012.128
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发表时间：
2012-09
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影响因子：
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Osteoarthritis (OA) is the most common musculoskeletal disorder. It is a complex and multifaceted disease, characterized by the degradation of articular cartilage and joint inflammation. Although few pathogenesis pathways have been characterized, current knowledge is incomplete and has not led to effective approaches for prevention or treatment. These limitations can be overcome by advances in the understanding of molecular mechanisms that are involved in the maintenance and destruction of articular cartilage. Understanding extracellular regulators and intracellular signaling mechanisms in joint cells that control cartilage homeostasis has the potential to lead to the identification of new therapeutic targets for OA. Recently, non-coding RNAs, miRNAs, was noted to act as novel regulatory molecules that regulated the expression of several target genes. The major role of miRNAs is to control development and tissue homeostasis through the ‘fine-tuning’ of the gene expression. Several miRNAs exhibit a tissue- or developmental stage-specific expression pattern and have been associated with diseases such as cancer and cardiovascular disorders. This review is based on our observations that miRNAs play an important role in cartilage homeostasis, and is to summarize the information on miRNA involved in OA pathogenesis, and its clinical approach.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
64.5
作者：
Hafner M;Landthaler M;Burger L;Khorshid M;Hausser J;Berninger P;Rothballer A;Ascano M Jr;Jungkamp AC;Munschauer M;Ulrich A;Wardle GS;Dewell S;Zavolan M;Tuschl T
通讯作者：
Tuschl T
影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
影响因子：
56.9
作者：
Farh, KKH;Grimson, A;Bartel, DP
通讯作者：
Bartel, DP
影响因子：
46.9
作者：
通讯作者：
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