Healthcare utilization is a collider: an introduction to collider bias in EHR data reuse.
Healthcare utilization is a collider: an introduction to collider bias in EHR data reuse.
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DOI:
10.1093/jamia/ocad013
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发表时间:
2023-04-19
影响因子:
6.4
通讯作者:
Thompson, Caroline A.
中科院分区:
文献类型:
--
作者:
Weiskopf, Nicole G.;Dorr, David A.;Jackson, Christie;Lehmann, Harold P.;Thompson, Caroline A.
Collider bias is a common threat to internal validity in clinical research but is rarely mentioned in informatics education or literature. Conditioning on a collider, which is a variable that is the shared causal descendant of an exposure and outcome, may result in spurious associations between the exposure and outcome. Our objective is to introduce readers to collider bias and its corollaries in the retrospective analysis of electronic health record (EHR) data. Collider bias is likely to arise in the reuse of EHR data, due to data-generating mechanisms and the nature of healthcare access and utilization in the United States. Therefore, this tutorial is aimed at informaticians and other EHR data consumers without a background in epidemiological methods or causal inference. We focus specifically on problems that may arise from conditioning on forms of healthcare utilization, a common collider that is an implicit selection criterion when one reuses EHR data. Directed acyclic graphs (DAGs) are introduced as a tool for identifying potential sources of bias during study design and planning. References for additional resources on causal inference and DAG construction are provided.
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影响因子:
7.7
作者:
Textor, Johannes;van der Zander, Benito;Ellison, George T. H.
通讯作者:
Ellison, George T. H.
DOI:
10.1136/amiajnl-2013-001935
发表时间:
2014-03
期刊:
Journal of the American Medical Informatics Association : JAMIA
影响因子:
--
作者:
Shivade C;Raghavan P;Fosler-Lussier E;Embi PJ;Elhadad N;Johnson SB;Lai AM
通讯作者:
Lai AM
影响因子:
3.1
作者:
Bastarache L;Brown JS;Cimino JJ;Dorr DA;Embi PJ;Payne PRO;Wilcox AB;Weiner MG
通讯作者:
Weiner MG
影响因子:
3.4
作者:
Merdler-Rabinowicz, Rona;Tiosano, Shmuel;Amital, Howard
通讯作者:
Amital, Howard
影响因子:
33.9
作者:
Okoro, Catherine A.;Hollis, NaTasha D.;Griffin-Blake, Shannon
通讯作者:
Griffin-Blake, Shannon