A Deep Brain Stimulation Trial Period for Treating Chronic Pain.
A Deep Brain Stimulation Trial Period for Treating Chronic Pain.
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DOI：
10.3390/jcm9103155
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发表时间：
2020-09-29
影响因子：
3.9
通讯作者：
Chang EF
中科院分区：
文献类型：
--
作者：
Shirvalkar P;Sellers KK;Schmitgen A;Prosky J;Joseph I;Starr PA;Chang EF
脑深部电刺激（DBS）用于治疗各种神经系统疾病的早期研究涉及临时试验期，其中植入的电极被外部化，其中离开患者大脑的电触点连接到外部刺激设备，以便在永久植入之前确定刺激功效。作为各种疾病的最佳脑靶位点（即，帕金森氏病，特发性震颤）变得更好地建立，这样的试验期已经失宠。然而，脑深部电刺激试验期正在经历现代复苏，原因至少有两个：（1）对抑郁症或慢性疼痛等新适应症的研究旨在确定新的靶点，以及（2）对自适应DBS工具的兴趣日益增长，需要进行神经生理学记录，这通常在围手术期进行。在这篇综述中，我们考虑了这种住院试验期的可能方法、获益和风险，特别关注开发新的DBS治疗慢性疼痛。
Early studies of deep brain stimulation (DBS) for various neurological disorders involved a temporary trial period where implanted electrodes were externalized, in which the electrical contacts exiting the patient’s brain are connected to external stimulation equipment, so that stimulation efficacy could be determined before permanent implant. As the optimal brain target sites for various diseases (i.e., Parkinson’s disease, essential tremor) became better established, such trial periods have fallen out of favor. However, deep brain stimulation trial periods are experiencing a modern resurgence for at least two reasons: (1) studies of newer indications such as depression or chronic pain aim to identify new targets and (2) a growing interest in adaptive DBS tools necessitates neurophysiological recordings, which are often done in the peri-surgical period. In this review, we consider the possible approaches, benefits, and risks of such inpatient trial periods with a specific focus on developing new DBS therapies for chronic pain.
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影响因子：
4.1
作者：
de Almeida, AN;Olivier, A;Andermann, F
通讯作者：
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