Melatonin-induced temporal up-regulation of gene expression related to ubiquitin/proteasome system (UPS) in the human malaria parasite Plasmodium falciparum.
Melatonin-induced temporal up-regulation of gene expression related to ubiquitin/proteasome system (UPS) in the human malaria parasite Plasmodium falciparum.
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DOI：
10.3390/ijms151222320
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发表时间：
2014-12-03
影响因子：
5.6
通讯作者：
Garcia CR
中科院分区：
文献类型：
--
作者：
Koyama FC;Azevedo MF;Budu A;Chakrabarti D;Garcia CR
越来越多的人认识到褪黑素和泛素/蛋白酶体系统（UPS）相互作用，调节多种细胞功能。泛素化等翻译后修饰是信号过程、细胞周期和许多其他细胞功能的重要调节剂。此前，我们报道了褪黑激素诱导的恶性疟原虫（疟原虫）中泛素/蛋白酶体系统（UPS）相关基因表达上调，以及恶性疟原虫蛋白激酶7影响这一过程。这意味着褪黑激素（一种吲哚胺）在调节寄生虫红细胞内发育中的作用。在本报告中，我们通过qPCR分析证明，褪黑激素在褪黑激素治疗后4至5小时内，诱导14个UPS基因中的9个基因上调，这些基因由先前报道的同一组基因组成。我们证明褪黑激素导致UPS成员暂时控制基因表达。
There is an increasing understanding that melatonin and the ubiquitin/proteasome system (UPS) interact to regulate multiple cellular functions. Post-translational modifications such as ubiquitination are important modulators of signaling processes, cell cycle and many other cellular functions. Previously, we reported a melatonin-induced upregulation of gene expression related to ubiquitin/proteasome system (UPS) in Plasmodium falciparum, the human malaria parasite, and that P. falciparum protein kinase 7 influences this process. This implies a role of melatonin, an indolamine, in modulating intraerythrocytic development of the parasite. In this report we demonstrate by qPCR analysis, that melatonin induces gene upregulation in nine out of fourteen genes of the UPS, consisting of the same set of genes previously reported, between 4 to 5 h after melatonin treatment. We demonstrate that melatonin causes a temporally controlled gene expression of UPS members.
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影响因子：
3.7
作者：
Madeira L;Galante PA;Budu A;Azevedo MF;Malnic B;Garcia CR
通讯作者：
Garcia CR
影响因子：
1.5
作者：
Farias, SL;Gazarini, ML;Garcia, CRS
通讯作者：
Garcia, CRS
影响因子：
9.8
作者：
Bozdech, Zbynek;Llinas, Manuel;Pulliam, Brian Lee;Wong, Edith D;Zhu, Jingchun;DeRisi, Joseph L
通讯作者：
DeRisi, Joseph L
影响因子：
10.3
作者：
Beraldo, Flavlo H.;Mikoshiba, Katsuhiko;Garcia, Celia R. S.
通讯作者：
Garcia, Celia R. S.
影响因子：
3
作者：
Garcia, CRS;Takeuschi, M;Miyamoto, H
通讯作者：
Miyamoto, H