The use of the reinstatement model to study relapse to palatable food seeking during dieting.
The use of the reinstatement model to study relapse to palatable food seeking during dieting.
复制标题
DOI：
10.1016/j.neuropharm.2013.04.030
复制
发表时间：
2014-01
影响因子：
4.7
通讯作者：
Shaham Y
中科院分区：
文献类型：
--
作者：
Calu DJ;Chen YW;Kawa AB;Nair SG;Shaham Y
过度消费不健康食品是一个重大的公共卫生问题。虽然许多人试图通过节食来控制他们的食物摄入量，但许多人在几个月内就会重新陷入不健康的饮食习惯。我们已经开始研究这种临床条件下，在大鼠适应恢复模型，已被广泛用于研究复发药物寻求。在我们的适应复发模型，恢复可口的食物寻求暴露于食物颗粒启动，食物相关的线索，或压力进行评估后，操作性食物颗粒自我管理的培训和随后的灭绝的食物强化反应的食物限制（模仿节食）大鼠。在这篇综述中，我们首先概述了临床问题，并讨论了最近的一项研究中，我们评估了恢复模型的预测有效性，研究复发的食物寻求在节食期间使用的促生长药物芬氟拉明。接下来，我们总结了我们对几种应激和进食相关肽（促肾上腺皮质激素释放因子，下丘脑泌素，黑色素浓缩激素，肽YY 3 -36）在恢复美味食物寻求中的作用的初步研究结果。然后，我们提出的结果，从我们的研究中的作用，多巴胺和内侧前额叶皮层的压力诱导恢复的食物寻求。最后，我们讨论了潜在的临床意义。我们得出两个主要结论：（1）食物恢复模型是一种简单、可靠和有效的模型，可用于研究节食期间对可口食物寻求的复发机制，并确定预防这种复发的药物;（2）食物寻求复发的机制通常与持续食物摄入的机制无关。
Excessive consumption of unhealthy foods is a major public health problem. While many people attempt to control their food intake through dieting, many relapse to unhealthy eating habits within a few months. We have begun to study this clinical condition in rats by adapting the reinstatement model, which has been used extensively to study relapse to drug seeking. In our adaptation of the relapse model, reinstatement of palatable food seeking by exposure to food-pellet priming, food-associated cues, or stress is assessed in food-restricted (to mimic dieting) rats after operant food-pellet self-administration training and subsequent extinction of the food-reinforced responding. In this review, we first outline the clinical problem and discuss a recent study in which we assessed the predictive validity of the reinstatement model for studying relapse to food seeking during dieting by using the anorexigenic drug fenfluramine. Next, we summarize results from our initial studies on the role of several stress- and feeding-related peptides (corticotropin-releasing factor, hypocretin, melanin- concentrating hormone, peptide YY3-36) in reinstatement of palatable food seeking. We then present results from our studies on the role of dopamine and medial prefrontal cortex in stress-induced reinstatement of food seeking. We conclude by discussing potential clinical implications. We offer two main conclusions: (1) the food reinstatement model is a simple, reliable, and valid model to study mechanisms of relapse to palatable food seeking during dieting, and to identify medications to prevent this relapse; (2) mechanisms of relapse to food seeking are often dissociable from mechanisms of ongoing food intake.
登录
查看更多内容
DOI：
10.1073/pnas.0507480102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Boutrel, B;Kenny, PJ;de Lecea, L
通讯作者：
de Lecea, L
影响因子：
5.3
作者：
Barth, AL;Gerkin, RC;Dean, KL
通讯作者：
Dean, KL
DOI：
10.1523/jneurosci.2246-11.2011
发表时间：
2011-07-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Adamantidis AR;Tsai HC;Boutrel B;Zhang F;Stuber GD;Budygin EA;Touriño C;Bonci A;Deisseroth K;de Lecea L
通讯作者：
de Lecea L
影响因子：
7.3
作者：
BRIGGS, CA;POLLOCK, NJ;KEBABIAN, JW
通讯作者：
KEBABIAN, JW
影响因子：
29.4
作者：
ADRIAN, TE;FERRI, GL;BLOOM, SR
通讯作者：
BLOOM, SR