Radiotherapy and Cytokine Storm: Risk and Mechanism.
Radiotherapy and Cytokine Storm: Risk and Mechanism.
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放射治疗和细胞因子风暴：风险和机制
DOI：
10.3389/fonc.2021.670464
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发表时间：
2021
影响因子：
4.7
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Zhang C;Liang Z;Ma S;Liu X
放射治疗(RT)作为肿瘤治疗最重要的精确治疗策略之一显示出其优势，尤其是大剂量低分割放射治疗因其对局部解剖结构的保护和相对较轻的损伤而被广泛应用于临床。随着2~20Gy单剂量照射剂量的增加和分割剂量的减少，不同治疗方案是否有统一的剂量限值的问题越来越受到人们的关注，高剂量辐射的潜在不良反应也没有得到阐明。本研究旨在阐明放射治疗引起的免疫不良反应，特别是细胞因子风暴及其机制，如抑制因子释放、促炎性细胞因子分泌、cGAS-STING通路激活等，以期达到最佳的低分割放疗方案，提高对癌细胞的杀伤率，避免严重的副作用。
Radiotherapy (RT) shows advantages as one of the most important precise therapy strategies for cancer treatment, especially high-dose hypofractionated RT which is widely used in clinical applications due to the protection of local anatomical structure and relatively mild impairment. With the increase of single dose, ranging from 2~20 Gy, and the decrease of fractionation, the question that if there is any uniform standard of dose limits for different therapeutic regimens attracts more and more attention, and the potential adverse effects of higher dose radiation have not been elucidated. In this study, the immunological adverse responses induced by radiation, especially the cytokine storm and the underlying mechanisms such as DAMPs release, pro-inflammatory cytokine secretion and cGAS-STING pathway activation, will be elucidated, which contributes to achieving optimal hypofractionated RT regimen, improving the killing of cancer cells and avoiding the severe side effects.
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影响因子：
82.9
作者：
Giavridis T;van der Stegen SJC;Eyquem J;Hamieh M;Piersigilli A;Sadelain M
通讯作者：
Sadelain M
影响因子：
10.9
作者：
Barker CA;Kim SK;Budhu S;Matsoukas K;Daniyan AF;D'Angelo SP
通讯作者：
D'Angelo SP
影响因子：
51.1
作者：
Herrera, Fernando G.;Irving, Melita;Coukas, George
通讯作者：
Coukas, George
影响因子：
3.1
作者：
Alig, Stefan K.;Dreyling, Martin;Rieger, Christina T.
通讯作者：
Rieger, Christina T.
DOI：
10.1038/nrc3958
发表时间：
2015-07
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Barker HE;Paget JT;Khan AA;Harrington KJ
通讯作者：
Harrington KJ