Physical models for exploring DNA topology.

Physical models for exploring DNA topology.
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用于探索 DNA 拓扑的物理模型。

DOI:
10.1080/07391102.1988.10506445
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发表时间:
1988
影响因子:
4.4
通讯作者:
Seeman,NC
Seeman,NC
中科院分区:
生物学3区
文献类型:
--
作者:
Seeman,NC

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已经开发出两种类型的物理模型来处理感兴趣的拓扑结构的 DNA 分子。这两种模型主题将千斤顶和吸管分子表示与不同比例的柔性管相结合。两种基序都呈现出低分辨率的 DNA 结构,保留了螺旋轴、链的个性以及主沟和小沟的可区分性。双螺旋轴分支的分子由刚性双螺旋和柔性分支位点建模。超螺旋和打结的 DNA 分子在较小的规模上建模,在一个由一系列刚性螺旋支柱支撑柔性骨架的系统中;移除这个脚手架会立即显示出链的连接。这些模型重量轻且易于构建。它们可以用于演示或作为辅助解释数据的研究工具。
Two types of physical models have been developed for treating DNA molecules whose topology is of interest The two model motifs combine jacks-and-straws molecular representations with flexible tubing in different proportions. Both motifs present a low-resolution construct of DNA that retains helix axes, strand individuality and the distinguishabiity of the major and minor grooves. Molecules whose double helix axes are branched are modelled by stiff double helices and flexible branch sites. Supercoiled and knotted DNA molecules are modelled on a smaller scale, in a system in which a flexible backbone is supported by a series of stiff helical struts; removal of this scaffolding immediately reveals the linking of the strands. The models are light and easy to construct. They may be used either for demonstrations or as a research tool that assists the interpretation data.
DOI: 10.1002/bip.1981.360200615
发表时间: 1981-01-01
期刊: BIOPOLYMERS
影响因子: 2.9
作者:
BRIAN, AA;FRISCH, HL;LERMAN, LS
通讯作者: LERMAN, LS
遗传重组:两个同源 DNA 分子之间交叉链交换的本质。
DOI: --
发表时间: 1972
影响因子: 5.6
作者:
Nolan H. Sigal;B. Alberts
通讯作者: B. Alberts
DOI: 10.1093/nar/14.24.9745
发表时间: 1986-12-22
影响因子: 14.9
作者:
MA, RI;KALLENBACH, NR;SEEMAN, NC
通讯作者: SEEMAN, NC
DOI: 10.1038/hdy.1977.39
发表时间: 1977
期刊: Heredity
影响因子: 3.8
作者:
S. McGavin
通讯作者: S. McGavin
DOI: 10.1016/0968-0004(86)90130-1
发表时间: 1986-04-01
影响因子: 13.8
作者:
HAREL, D;UNGER, R;SUSSMAN, JL
通讯作者: SUSSMAN, JL