Primordial super-enhancers: heat shock-induced chromatin organization in yeast.
Primordial super-enhancers: heat shock-induced chromatin organization in yeast.
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DOI：
10.1016/j.tcb.2021.04.004
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发表时间：
2021-10
影响因子：
19
通讯作者：
Gross DS
中科院分区：
文献类型：
--
作者：
Kainth AS;Chowdhary S;Pincus D;Gross DS
专门的机制确保关键重要基因的适当表达，例如那些指定细胞身份或赋予保护免受环境压力的基因。对热休克反应的研究对于阐明转录调控的基本概念至关重要。最近的研究表明，热休克反应基因与高水平的转录激活子和共激活子相关，而酵母中的那些基因在染色体上和染色体之间强烈相互作用，结合成凝集物。在哺乳动物细胞中，受超级增强子(SE)调控的细胞识别基因也被转录机制密集占据，形成相分离的凝聚体。我们认为，应激改造的酵母核组在功能和结构上与哺乳动物的SE相似，并将揭示转录缩合物控制基因的基本机制。
Specialized mechanisms ensure proper expression of critically important genes such as those specifying cell identity or conferring protection from environmental stress. Investigations of the heat shock response have been critical in elucidating basic concepts of transcriptional control. Recent studies demonstrate that in response to thermal stress, heat shock-responsive genes associate with high levels of transcriptional activators and co-activators and those in yeast intensely interact across and between chromosomes, coalescing into condensates. In mammalian cells, cell identity genes that are regulated by super-enhancers (SEs) are also densely occupied by transcriptional machinery that form phase-separated condensates. We suggest that the stress-remodeled yeast nucleome bears functional and structural resemblance to mammalian SEs, and will reveal fundamental mechanisms of gene control by transcriptional condensates.
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影响因子：
14.9
作者：
The Gene Ontology Consortium
通讯作者：
The Gene Ontology Consortium
影响因子：
64.5
作者：
Dowen JM;Fan ZP;Hnisz D;Ren G;Abraham BJ;Zhang LN;Weintraub AS;Schujiers J;Lee TI;Zhao K;Young RA
通讯作者：
Young RA
影响因子：
5.3
作者：
Anandhakumar, Jayamani;Moustafa, Yara W.;Gross, David S.
通讯作者：
Gross, David S.
影响因子：
64.5
作者：
Boija A;Klein IA;Sabari BR;Dall'Agnese A;Coffey EL;Zamudio AV;Li CH;Shrinivas K;Manteiga JC;Hannett NM;Abraham BJ;Afeyan LK;Guo YE;Rimel JK;Fant CB;Schuijers J;Lee TI;Taatjes DJ;Young RA
通讯作者：
Young RA
影响因子：
3.9
作者：
Dekker J
通讯作者：
Dekker J