The Gene Ontology Resource: 20 years and still GOing strong.
The Gene Ontology Resource: 20 years and still GOing strong.
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DOI：
10.1093/nar/gky1055
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发表时间：
2019-01-08
影响因子：
14.9
通讯作者：
The Gene Ontology Consortium
中科院分区：
文献类型：
--
作者：
The Gene Ontology Consortium
基因本体资源（GO; http://geneontology.org）提供了关于基因和基因产物功能的结构化、可计算的知识。GO自1998年成立以来，已被广泛应用于生命科学领域，其内容在数量和质量上都在不断改进。在这里，我们报告的GO资源在过去两年的主要发展。GO资源的每个月度发布现在都被打包并赋予一个唯一的标识符（DOI），从而使基于GO的分析能够在未来重现。分子功能本体已被重构，以更好地代表基因产物的整体活动，重点是转录调节活性。质量保证工作已经加强，以解决可能过时或不准确的注释。用于高通量实验的新证据代码现在使用户能够过滤掉从这些来源获得的注释。GO-CAM是一种新的表达基因功能的框架，比标准的GO注释更具表达力，已经发布，用户现在可以探索这些模型的不断增长的存储库。我们还提供了“GO ribbon”小部件，用于可视化基因的GO注释;该小部件可以轻松嵌入任何网页。
The Gene Ontology resource (GO; http://geneontology.org) provides structured, computable knowledge regarding the functions of genes and gene products. Founded in 1998, GO has become widely adopted in the life sciences, and its contents are under continual improvement, both in quantity and in quality. Here, we report the major developments of the GO resource during the past two years. Each monthly release of the GO resource is now packaged and given a unique identifier (DOI), enabling GO-based analyses on a specific release to be reproduced in the future. The molecular function ontology has been refactored to better represent the overall activities of gene products, with a focus on transcription regulator activities. Quality assurance efforts have been ramped up to address potentially out-of-date or inaccurate annotations. New evidence codes for high-throughput experiments now enable users to filter out annotations obtained from these sources. GO-CAM, a new framework for representing gene function that is more expressive than standard GO annotations, has been released, and users can now explore the growing repository of these models. We also provide the ‘GO ribbon’ widget for visualizing GO annotations to a gene; the widget can be easily embedded in any web page.
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基因本体论：2011年的增强。
影响因子：
14.9
作者：
Gene Ontology Consortium
通讯作者：
Gene Ontology Consortium
影响因子：
12.3
作者：
通讯作者：
--
影响因子：
14.9
作者：
Federhen S
通讯作者：
Federhen S
影响因子：
4.9
作者：
Cooper L;Walls RL;Elser J;Gandolfo MA;Stevenson DW;Smith B;Preece J;Athreya B;Mungall CJ;Rensing S;Hiss M;Lang D;Reski R;Berardini TZ;Li D;Huala E;Schaeffer M;Menda N;Arnaud E;Shrestha R;Yamazaki Y;Jaiswal P
通讯作者：
Jaiswal P
DOI：
10.1093/database/baw155
发表时间：
2016-12-26
影响因子：
5.8
作者：
Feuermann, Marc;Gaudet, Pascale;Thomas, Paul D.
通讯作者：
Thomas, Paul D.