The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
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DOI：
10.4049/jimmunol.181.5.3413
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发表时间：
2008-09-01
影响因子：
4.4
通讯作者：
Sorensen, Ole E.
中科院分区：
文献类型：
--
作者：
Edstrom, Anneli M. L.;Malm, Johan;Frohm, Birgitta;Martellini, Julie A.;Giwercman, Aleksander;Morgelin, Matthias;Cole, Alexander M.;Sorensen, Ole E.
精浆的主要作用之一是为女性生殖道中的精子提供抗菌保护。我们发现精浆的杀菌活性在精液凝块消退后最高，而这种抗菌活性随后大大减弱。其抗菌活性来源于精凝素片段化产生的肽段，而精凝素全蛋白则没有抗菌活性。射精后，精液凝固蛋白衍生的肽随着时间的推移被片段化为越来越小的片段，从而失去抗菌活性。这说明整个精浆在体外和性交后都丧失了抗菌活性。此外，在精浆中产生的精液凝固蛋白衍生肽的抗菌活性是严格的锌依赖性在中性和低pH值。这些数据提供了新的作用，为解决精液凝块和高锌浓度的人精浆。
One of the major roles of seminal plasma is to provide antimicrobial protection for the spermatozoa in the female reproductive tract. We found that the bactericidal activity of seminal plasma was highest after resolution of the seminal clot and that this antibacterial activity subsequently became greatly diminished. The antibacterial activity was derived from peptides generated by fragmentation of the semenogelins while the semenogelin holoproteins displayed no antibacterial activity. After ejaculation the semenogelin-derived peptides were fragmented to smaller and smaller fragments over time and thereby lost antibacterial activity. This paralleled the loss of antibacterial activity of whole seminal plasma both in vitro and after sexual intercourse. Moreover, the antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH. These data provide novel roles for the resolution of seminal clots and for the high zinc concentration in human seminal plasma.
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影响因子：
4.4
作者：
Venkataraman, N;Cole, AL;Cole, AM
通讯作者：
Cole, AM
影响因子：
--
作者：
WICHMANN, L;VAALASTI, A;TUOHIMAA, P
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Hall, SH
影响因子：
3.4
作者：
Kacprzyk, Lukasz;Rydengard, Victoria;Schmidtchen, Artur
通讯作者：
Schmidtchen, Artur