More than a pore: the cellular response to cholesterol-dependent cytolysins.
More than a pore: the cellular response to cholesterol-dependent cytolysins.
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DOI：
10.3390/toxins5040618
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发表时间：
2013-04-12
期刊：
影响因子：
4.2
通讯作者：
O'Riordan MX
中科院分区：
文献类型：
--
作者：
Cassidy SK;O'Riordan MX
有针对性地破坏质膜是一种普遍存在的攻击形式，用于生命的所有三个领域。许多细菌在感染过程中分泌成孔蛋白，这对发病机制有广泛的影响。胆固醇依赖性溶细胞素（CDC）是主要由革兰氏阳性细菌病原体表达的成孔毒素家族。已经描述了这些寡聚毒素中的一些在宿主膜上的结构和组装，但是靶细胞如何响应CDC的中毒还不清楚。许多CDC诱导其靶细胞的裂解，并且可以激活凋亡级联以促进细胞死亡。然而，中毒导致细胞死亡的程度是CDC和宿主细胞依赖性的，并且在较低浓度的毒素下，中毒宿主细胞的存活是有据可查的。此外，CDC的作用可以在质膜之外看到，并且越来越清楚的是，这些毒素是信号传导和免疫的有效调节剂，而不仅仅是它们在中毒中的作用。在这篇综述中，我们讨论了CDC中毒的细胞反应，强调孔形成对宿主细胞质膜和亚细胞器的影响，以及随后的细胞反应是否有助于受影响细胞的存活。
Targeted disruption of the plasma membrane is a ubiquitous form of attack used in all three domains of life. Many bacteria secrete pore-forming proteins during infection with broad implications for pathogenesis. The cholesterol-dependent cytolysins (CDC) are a family of pore-forming toxins expressed predominately by Gram-positive bacterial pathogens. The structure and assembly of some of these oligomeric toxins on the host membrane have been described, but how the targeted cell responds to intoxication by the CDCs is not as clearly understood. Many CDCs induce lysis of their target cell and can activate apoptotic cascades to promote cell death. However, the extent to which intoxication causes cell death is both CDC- and host cell-dependent, and at lower concentrations of toxin, survival of intoxicated host cells is well documented. Additionally, the effect of CDCs can be seen beyond the plasma membrane, and it is becoming increasingly clear that these toxins are potent regulators of signaling and immunity, beyond their role in intoxication. In this review, we discuss the cellular response to CDC intoxication with emphasis on the effects of pore formation on the host cell plasma membrane and subcellular organelles and whether subsequent cellular responses contribute to the survival of the affected cell.
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影响因子：
5.8
作者：
Dogan, Semih;Zhang, Qibo;Murdoch, Craig
通讯作者：
Murdoch, Craig
影响因子：
3.7
作者：
Carrero JA;Vivanco-Cid H;Unanue ER
通讯作者：
Unanue ER
在质膜修复流量中，内吞毒素孔进入MVB的流水中以降解。
DOI：
10.1111/j.1600-0854.2011.01323.x
发表时间：
2012-03
期刊：
Traffic (Copenhagen, Denmark)
影响因子：
--
作者：
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通讯作者：
Andrews NW
影响因子：
2.9
作者：
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通讯作者：
Heuck, Alejandro P.
影响因子：
6.8
作者：
Dunstone MA;Tweten RK
通讯作者：
Tweten RK