Adaptive functioning of childhood brain tumor survivors following conformal radiation therapy.
Adaptive functioning of childhood brain tumor survivors following conformal radiation therapy.
复制标题
共形放射治疗后，儿童脑肿瘤幸存者的适应性功能。
DOI：
10.1007/s11060-014-1420-7
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发表时间：
2014-05
影响因子：
3.9
通讯作者：
Conklin, Heather M.
中科院分区：
文献类型：
--
作者：
Ashford, Jason M.;Netson, Kelli L.;Clark, Kellie N.;Merchant, Thomas E.;Santana, Victor M.;Wu, Shengjie;Conklin, Heather M.
适应功能在儿童期脑肿瘤（BT）幸存者中并不常见，现有的研究很少依赖于检查者访谈。家长问卷可以提供类似的信息，减少负担。本研究的目的是：（1）检查BT幸存者相对于健康同龄人和癌症幸存者群体的适应行为，（2）探讨父母问卷的有效性与考官管理的访谈。参与者（年龄13.11±2.98岁）为接受适形放射治疗的BT幸存者（n=50），BT幸存者的健康兄弟姐妹（n=39）和未接受CNS定向治疗的实体瘤（ST）幸存者（n=40）。家长完成适应性行为评估系统-第二版（ABAS-II）。对于BT队列的一个子集（n=32），检查员在12个月内使用Vineland适应行为量表（VABS）采访了父母。各组在每个ABAS-II指数和一般适应性复合指标上存在显著差异，BT组的各项指数得分低于兄弟姐妹和ST组。执行功能（而不是智商）与适应技能相关;尚未建立明确的临床和人口统计预测因素模式。VABS评分与ABAS-II评分几乎所有指标相关。与健康和癌症对照组相比，BT幸存者的适应功能显着降低。ABAS-II被证明对这些行为限制敏感，并且与VABS评分一致。使用父母问卷来评估适应功能，通过增加评估的灵活性和减少检查者的负担来增强生存率调查。
Adaptive functioning is not often examined in childhood brain tumor (BT) survivors, with the few existing investigations relying on examiner interviews. Parent questionnaires may provide similar information with decreased burden. The purpose of this study was: (1) to examine adaptive behaviors in BT survivors relative to healthy peer and cancer survivor groups, and (2) to explore the validity of a parent questionnaire in relation to an examiner administered interview. Participants (age 13.11±2.98 years) were BT survivors treated with conformal radiation therapy (n=50), healthy siblings of BT survivors (n=39) and solid tumor (ST) survivors who did not receive CNS-directed therapy (n=40). Parents completed the Adaptive Behavior Assessment System–2nd Edition (ABAS-II). For a subset of the BT cohort (n=32), examiners interviewed the parents using the Vineland Adaptive Behavior Scales (VABS) within 12 months. Groups differed significantly on each of the ABAS-II indices and the general adaptive composite, with the BT group scoring lower than the sibling and ST groups across indices. Executive functioning, but not IQ, was associated with adaptive skills; no clear pattern of clinical and demographic predictors was established. VABS scores were correlated with ABAS-II scores on nearly all indices. BT survivors showed significantly lower adaptive functioning when compared to healthy and cancer controls. The ABAS-II proved sensitive to these behavioral limitations and was consistent with scores on the VABS. The use of a parent questionnaire to assess adaptive functioning enhances survivorship investigations by increasing flexibility of assessment and decreasing examiner burden.
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影响因子：
2.4
作者：
Mabbott, Donald J.;Witol, Adrienne;Bouffet, Eric
通讯作者：
Bouffet, Eric
DOI：
10.1017/s1355617712001567
发表时间：
2013-04
影响因子：
2.6
作者：
Howarth, Robyn A.;Ashford, Jason M.;Merchant, Thomas E.;Ogg, Robert J.;Santana, Victor;Wu, Shengjie;Xiong, Xiaoping;Conklin, Heather M.
通讯作者：
Conklin, Heather M.
影响因子：
7.2
作者：
Patterson, TL;McKibbin, C;Jeste, DV
通讯作者：
Jeste, DV
影响因子：
2.4
作者：
Ellenberg, Leah;Liu, Qi;Gioia, Gerard;Yasui, Yutaka;Packer, Roger J.;Mertens, Ann;Donaldson, Sarah S.;Stovall, Marilyn;Kadan-Lottick, Nina;Armstrong, Gregory;Robison, Leslie L.;Zeltzer, Lonnie K.
通讯作者：
Zeltzer, Lonnie K.
影响因子：
4.1
作者：
KUN, LE;MULHERN, RK;CRISCO, JJ
通讯作者：
CRISCO, JJ