3D prompt gamma imaging for proton beam range verification.
3D prompt gamma imaging for proton beam range verification.
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DOI：
10.1088/1361-6560/aaa203
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发表时间：
2018-01-30
影响因子：
3.5
通讯作者：
Polf JC
中科院分区：
文献类型：
--
作者：
Draeger E;Mackin D;Peterson S;Chen H;Avery S;Beddar S;Polf JC
我们测试了单个康普顿照相机（CC）产生三维（3D）图像的能力，即在用质子笔形束照射组织等效塑料体模期间发射的瞬发伽马（PG），以临床剂量率提供临床剂量。PG测量是用放置在质子束路径沿着三个不同位置的小型原型CC进行的。我们评估了CC在两种临床情况下在每个位置产生图像的能力：1）通过低分割治疗输送单个2 -戈伊笔形射束[~9 × 108个质子]，2）通过标准治疗输送单个笔形射束[~1 × 108个质子]。此外，将在每个位置测量的数据进行组合，以模拟更大规模的测量、临床CC及其在两种临床情况下布拉格峰（BP）范围内成像偏移的能力。使用我们的原型CC，可以看到BP远端的位置，CC放置在BP远端衰减近端或远端4 cm处。使用来自模拟全尺寸临床CC的数据，在输送少至1 × 108个质子的情况下产生PG发射的3D图像，并且对于2戈伊点的输送，可以检测到小至2 mm的质子束范围内的偏移。根据这些结果，我们得出结论，在临床射束输送条件下，使用单个CC进行质子范围验证的3D PG成像是可能的。
We tested the ability of a single Compton camera (CC) to produce 3-dimensional (3D) images of prompt gammas (PGs) emitted during the irradiation of a tissue-equivalent plastic phantom with proton pencil beams for clinical doses delivered at clinical dose rates. PG measurements were made with a small prototype CC placed at three different locations along the proton beam path. We evaluated the ability of the CC to produce images at each location for two clinical scenarios: 1) the delivery of a single 2 -Gy pencil beam from a hypo-fractionated treatment [~9 × 108 protons], and 2) a single pencil beam from a standard treatment [~1 × 108 protons]. Additionally, the data measured at each location were combined to simulate measurements with a larger scale, clinical CC and its ability to image shifts in the Bragg Peak (BP) range for both clinical scenarios. With our prototype CC, the location of the distal end of the BP could be seen with the CC placed up to 4 cm proximal or distal to the BP distal falloff. Using the data from the simulated full scale clinical CC, 3D images of the PG emission were produced with the delivery of as few as 1 × 108 protons, and shifts in the proton beam range as small as 2 mm could be detected for delivery of a 2 Gy spot. From these results we conclude that 3D PG imaging for proton range verification under clinical beam delivery conditions is possible with a single CC.
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影响因子：
3.5
作者：
Peterson SW;Robertson D;Polf J
通讯作者：
Polf J
DOI：
10.1109/tns.2016.2622162
发表时间：
2017-01-01
影响因子：
4.4
作者：
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通讯作者：
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DOI：
10.1016/j.nima.2010.10.031
发表时间：
2011-01-11
影响因子：
1.4
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通讯作者：
Enghardt, W.
影响因子：
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作者：
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通讯作者：
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影响因子：
1.3
作者：
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通讯作者：
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