Optimizing a three-stage Compton camera for measuring prompt gamma rays emitted during proton radiotherapy.
Optimizing a three-stage Compton camera for measuring prompt gamma rays emitted during proton radiotherapy.
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DOI：
10.1088/0031-9155/55/22/015
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发表时间：
2010-11-21
影响因子：
3.5
通讯作者：
Polf J
中科院分区：
文献类型：
--
作者：
Peterson SW;Robertson D;Polf J
在这项工作中，我们研究了使用三级康普顿相机来测量质子放射治疗患者发出的次级瞬发伽马射线。这项研究的目的是(1)开发一种专门为测量组织发射的瞬发伽马射线而设计的最佳三级康普顿相机，以及(2)确定使用这种优化的康普顿相机设计来测量质子束照射过程中发射的瞬发伽马射线并对其成像的可行性。在Geant4中，三级康普顿相机被建模为三个平行平面几何布置的高纯锗探测器级。最初，使用从0到15 MeV的各向同性伽马源来确定提供最佳探测效率的探测器级的横向宽度和厚度。然后，用照射组织体模的质子束代替伽马源，计算优化后的相机对发射的瞬发伽马的整体探测效率。对于所研究的几种最优相机设计，总的计算效率从~10−6到10−3瞬发伽马之间变化，每个质子入射到组织模体上。根据总体效率结果，我们认为三级康普顿相机可以检测到足够数量的瞬发伽马，以便在质子放射治疗期间测量和成像瞬发伽马辐射是可行的。
In this work, we investigate the use of a three-stage Compton camera to measure secondary prompt gamma rays emitted from patients treated with proton beam radiotherapy. The purpose of this study was (1) to develop an optimal three-stage Compton camera specifically designed to measure prompt gamma rays emitted from tissue and (2) to determine the feasibility of using this optimized Compton camera design to measure and image prompt gamma rays emitted during proton beam irradiation. The three-stage Compton camera was modeled in Geant4 as three high-purity germanium detector stages arranged in parallel-plane geometry. Initially, an isotropic gamma source ranging from 0 to 15 MeV was used to determine lateral width and thickness of the detector stages that provided the optimal detection efficiency. Then, the gamma source was replaced by a proton beam irradiating a tissue phantom to calculate the overall efficiency of the optimized camera for detecting emitted prompt gammas. The overall calculated efficiencies varied from ~10−6 to 10−3 prompt gammas detected per proton incident on the tissue phantom for several variations of the optimal camera design studied. Based on the overall efficiency results, we believe it feasible that a three-stage Compton camera could detect a sufficient number of prompt gammas to allow measurement and imaging of prompt gamma emission during proton radiotherapy.
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影响因子：
1.8
作者：
Ordonez, CE;Chang, W;Bolozdynya, A
通讯作者：
Bolozdynya, A
影响因子：
3.5
作者：
Knopf, A.;Parodi, K.;Paganetti, H.
通讯作者：
Paganetti, H.
DOI：
10.1016/s0168-9002(97)00048-x
发表时间：
1997-04-11
影响因子：
1.4
作者：
Brun, R;Rademakers, F
通讯作者：
Rademakers, F
DOI：
10.1016/s0168-9002(98)01093-6
发表时间：
1999-02-11
影响因子：
1.4
作者：
Lee, IY
通讯作者：
Lee, IY
影响因子：
3.5
作者：
Polf, J. C.;Peterson, S.;Trache, L.
通讯作者：
Trache, L.