Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency.
Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency.
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DOI：
10.3390/biom11111566
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发表时间：
2021-10-22
期刊：
影响因子：
5.5
通讯作者：
Dale JK
中科院分区：
文献类型：
--
作者：
Murray PJ;Ocana E;Meijer HA;Dale JK
Hes/Her家族中的几个成员是Notch信号通路的保守靶标，编码转录抑制因子，这些转录抑制因子可以二聚化、结合DNA和自我抑制。这种对转录的自动抑制可以产生动态平衡，并且在存在解释转录、剪接和运输等过程的延迟的情况下，会产生振荡。虽然以前的转录自动抑制模型倾向于将翻译等过程视为不受调控(因此是线性的)，但在这里，我们发展和探索了一个数学模型，该模型将转录的自身抑制与翻译的非线性调控结合在一起。结果表明，这种模型在没有时滞的情况下，可以产生兴奋性、动态平衡、振荡和间歇性等非线性动力学行为。这些结果表明，与单独调节转录相比，对翻译和转录的调节允许更丰富的行为范围。建议进行一些实验，以允许在Notch信号系统中实验检测到翻译和转录的自动调节的签名。
Several members of the Hes/Her family, conserved targets of the Notch signalling pathway, encode transcriptional repressors that dimerise, bind DNA and self-repress. Such autoinhibition of transcription can yield homeostasis and, in the presence of delays that account for processes such as transcription, splicing and transport, oscillations. Whilst previous models of autoinhibition of transcription have tended to treat processes such as translation as being unregulated (and hence linear), here we develop and explore a mathematical model that considers autoinhibition of transcription together with nonlinear regulation of translation. It is demonstrated that such a model can yield, in the absence of delays, nonlinear dynamical behaviours such as excitability, homeostasis, oscillations and intermittency. These results indicate that regulation of translation as well as transcription allows for a much richer range of behaviours than is possible with autoregulation of transcription alone. A number of experiments are suggested that would that allow for the signature of autoregulation of translation as well as transcription to be experimentally detected in a Notch signalling system.
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DOI：
10.1085/jgp.43.5.867
发表时间：
1960-05
期刊：
The Journal of general physiology
影响因子：
--
作者：
FITZHUGH R
通讯作者：
FITZHUGH R
影响因子：
16.6
作者：
Liao BK;Jörg DJ;Oates AC
通讯作者：
Oates AC
DOI：
10.1142/s021820251550030x
发表时间：
2015-06-15
影响因子：
3.5
作者：
Chaplain, Mark;Ptashnyk, Mariya;Sturrock, Marc
通讯作者：
Sturrock, Marc
影响因子：
2
作者：
Sturrock, Marc;Terry, Alan J.;Chaplain, Mark A. J.
通讯作者：
Chaplain, Mark A. J.
影响因子：
64.8
作者：
van Es, JH;van Gijn, ME;Clevers, H
通讯作者：
Clevers, H