Testing the role of circadian genes in conferring risk for psychiatric disorders.
Testing the role of circadian genes in conferring risk for psychiatric disorders.
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DOI：
10.1002/ajmg.b.32230
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发表时间：
2014-04
影响因子：
2.8
通讯作者：
Wray, Naomi R.
中科院分区：
文献类型：
--
作者：
Byrne, Enda M.;Heath, Andrew C.;Madden, Pamela A. F.;Pergadia, Michele L.;Hickie, Ian B.;Montgomery, Grant W.;Martin, Nicholas G.;Wray, Naomi R.
睡眠紊乱和昼夜节律紊乱是精神疾病的共同特征，许多研究小组假设昼夜节律基因的遗传变异与精神疾病之间存在关联。利用精神病学基因组学联盟（PGC）对精神分裂症、双相情感障碍和重度抑郁症的关联分析汇总数据，我们评估了编码分子钟成分基因中常见snp影响精神疾病风险的证据。首先，对21个核心昼夜节律基因进行了基于基因和SNP的p值分析。随后，研究人员分析了与控制昼夜节律有关的基因的扩展列表。经过多次比较校正后，没有一个昼夜节律基因与这三种疾病中的任何一种显著相关。先前涉及精神疾病病因的几个基因在p < 0.05的名义水平上没有显著的snp，并且在PGC数据集中包含的时钟基因候选研究中发现的变异在多次测试校正后都不显著。没有证据表明在人类细胞中与控制昼夜节律相关的基因中存在丰富的关联。我们的研究结果表明，编码分子钟成分的基因并不是很好的候选者，因为它们含有增加双相情感障碍、精神分裂症或重度抑郁症风险的常见变异。
Disturbed sleep and disrupted circadian rhythms are a common feature of psychiatric disorders, and many groups have postulated an association between genetic variants in circadian clock genes and psychiatric disorders. Using summary data from the association analyses of the Psychiatric Genomics Consortia (PGC) for schizophrenia, bipolar disorder and Major Depressive Disorder, we evaluated the evidence that common SNPs in genes encoding components of the molecular clock influence risk to psychiatric disorders. Initially, gene-based and SNP p-values were analysed for 21 core circadian genes. Subsequently, an expanded list of genes linked to control of circadian rhythms was analysed. After correcting for multiple comparisons, none of the circadian genes were significantly associated with any of the three disorders. Several genes previously implicated in the etiology of psychiatric disorders harboured no SNPs significant at the nominal level of p < 0.05, and none of the the variants identified in candidate studies of clock genes that were included in the PGC datasets were significant after correction for multiple testing. There was no evidence of an enrichment of associations in genes linked to control of circadian rhythms in human cells. Our results suggest that genes encoding components of the molecular clock are not good candidates for harbouring common variants that increase risk to bipolar disorder, schizophrenia or Major Depressive Disorder.
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DOI：
10.1002/ajmg.b.30714
发表时间：
2008-10-05
期刊：
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
影响因子：
--
作者：
Shi J;Wittke-Thompson JK;Badner JA;Hattori E;Potash JB;Willour VL;McMahon FJ;Gershon ES;Liu C
通讯作者：
Liu C
影响因子：
9.8
作者：
Liu, Jimmy Z.;Mcrae, Allan F.;Macgregor, Stuart
通讯作者：
Macgregor, Stuart
DOI：
10.1002/ajmg.b.30962
发表时间：
2010-01-01
影响因子：
2.8
作者：
Casamassima, Francesco;Huang, Jie;Perlis, Roy H.
通讯作者：
Perlis, Roy H.
影响因子：
30.8
作者：
Ferreira, Manuel A. R.;O'Donovan, Michael C.;Meng, Yan A.;Jones, Ian R.;Ruderfer, Douglas M.;Jones, Lisa;Fan, Jinbo;Kirov, George;Perlis, Roy H.;Green, Elaine K.;Smoller, Jordan W.;Grozeva, Detelina;Stone, Jennifer;Nikolov, Ivan;Chambert, Kimberly;Hamshere, Marian L.;Nimgaonkar, Vishwajit L.;Moskvina, Valentina;Thase, Michael E.;Caesar, Sian;Sachs, Gary S.;Franklin, Jennifer;Gordon-Smith, Katherine;Ardlie, Kristin G.;Gabriel, Stacey B.;Fraser, Christine;Blumenstiel, Brendan;Defelice, Matthew;Breen, Gerome;Gill, Michael;Morris, Derek W.;Elkin, Amanda;Muir, Walter J.;McGhee, Kevin A.;Williamson, Richard;MacIntyre, Donald J.;MacLean, Alan W.;Clair, David St;Robinson, Michelle;Van Beck, Margaret;Pereira, Ana C. P.;Kandaswamy, Radhika;McQuillin, Andrew;Collier, David A.;Bass, Nicholas J.;Young, Allan H.;Lawrence, Jacob;Ferrier, I. Nicol;Anjorin, Adebayo;Farmer, Anne;Curtis, David;Scolnick, Edward M.;McGuffin, Peter;Daly, Mark J.;Corvin, Aiden P.;Holmans, Peter A.;Blackwood, Douglas H.;Gurling, Hugh M.;Owen, Michael J.;Purcell, Shaun M.;Sklar, Pamela;Craddock, Nick
通讯作者：
Craddock, Nick
睡眠习惯和失眠的全基因组关联研究。
DOI：
10.1002/ajmg.b.32168
发表时间：
2013-07
影响因子：
2.8
作者：
Byrne, Enda M.;Gehrman, Philip R.;Medland, Sarah E.;Nyholt, Dale R.;Heath, Andrew C.;Madden, Pamela A. F.;Hickie, Ian B.;Van Duijn, Cornelia M.;Henders, Anjali K.;Montgomery, Grant W.;Martin, Nicholas G.;Wray, Naomi R.
通讯作者：
Wray, Naomi R.