Metabolic and Dynamic Profiling for Risk Assessment of Fluopyram, a Typical Phenylamide Fungicide Widely Applied in Vegetable Ecosystem.
Metabolic and Dynamic Profiling for Risk Assessment of Fluopyram, a Typical Phenylamide Fungicide Widely Applied in Vegetable Ecosystem.
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氟吡菌酰胺（一种广泛应用于蔬菜生态系统的典型苯酰胺类杀菌剂）的代谢和动态分析用于风险评估
DOI：
10.1038/srep33898
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发表时间：
2016-09-22
影响因子：
4.6
通讯作者：
Wang M
中科院分区：
文献类型：
--
作者：
Wei P;Liu Y;Li W;Qian Y;Nie Y;Kim D;Wang M
氟吡喃（Fluopyram）是一种典型的苯酰胺类杀菌剂，被广泛应用于防治真菌致病菌造成的果蔬产量损失。与生态和饮食风险高度相关，其在果蔬生态系统中的残留和代谢概况仍不清楚。本研究采用改良的QuEChERS （Quick, Easy, Cheap, Effective, Rugged and Safe）萃取法结合GC-MS/MS分析方法，对温室环境下番茄、黄瓜、辣椒等典型水果蔬菜中的氟嘧唑啉进行了研究。氟吡喃的耗散符合一级速率动力学方程，最大半衰期为5.7 d。氟吡喃分解为2-三氟甲基苯酰胺，随后生成3-氯-5-（三氟甲基）吡啶-2-乙酸和3-氯-5-（三氟甲基）吡啶酸是其普遍存在的代谢途径。此外，在7 ~ 21 d的收获前间隔（PHI），氟吡兰的发生率在0.0108 ~ 0.1603 mg/kg之间，并且计算出的危害商数（HQs）小于1，表明氟吡兰引起的水果蔬菜暂时安全食用，而不考虑代谢物的不确定毒性。综上所述，我们的研究结果揭示了氟吡兰在典型农业生态系统中的残留本质，并将进一步深入了解这种杀菌剂及其代谢物所带来的生态风险。
Fluopyram, a typical phenylamide fungicide, was widely applied to protect fruit vegetables from fungal pathogens-responsible yield loss. Highly linked to the ecological and dietary risks, its residual and metabolic profiles in the fruit vegetable ecosystem still remained obscure. Here, an approach using modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction combined with GC-MS/MS analysis was developed to investigate fluopyram fate in the typical fruit vegetables including tomato, cucumber, pepper under the greenhouse environment. Fluopyram dissipated in accordance with the first-order rate dynamics equation with the maximum half-life of 5.7 d. Cleveage of fluopyram into 2-trifluoromethyl benzamide and subsequent formation of 3-chloro-5-(trifluoromethyl) pyridine-2-acetic acid and 3-chloro-5-(trifluoromethyl) picolinic acid was elucidated to be its ubiquitous metabolic pathway. Moreover, the incurrence of fluopyram at the pre-harvest interval (PHI) of 7–21 d was between 0.0108 and 0.1603 mg/kg, and the Hazard Quotients (HQs) were calculated to be less than 1, indicating temporary safety on consumption of the fruit vegetables incurred with fluopyram, irrespective of the uncertain toxicity of the metabolites. Taken together, our findings reveal the residual essential of fluopyram in the typical agricultural ecosystem, and would advance the further insight into ecological risk posed by this fungicide associated with its metabolites.
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