Perinatal acidosis and hypoxic-ischemic encephalopathy in preterm infants of 33 to 35 weeks' gestation.
Perinatal acidosis and hypoxic-ischemic encephalopathy in preterm infants of 33 to 35 weeks' gestation.
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DOI：
10.1016/j.jpeds.2011.09.001
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发表时间：
2012-03
影响因子：
5.1
通讯作者：
Sanchez, Pablo J.
中科院分区：
文献类型：
--
作者：
Chalak, Lina F.;Rollins, Nancy;Morriss, Michael C.;Brion, Luc P.;Heyne, Roy;Sanchez, Pablo J.
通过围产期酸中毒生理筛查和脑病神经学评估，确定33 ~ 35周胎龄早产儿缺氧缺血性脑病（HIE）的发生频率，并将神经发育结局与脑磁共振成像结果相关联。这项回顾性队列研究包括2005年10月至2008年9月在帕克兰纪念医院新生儿重症监护室接受围产期酸中毒的所有33至35周的新生儿。审查了他们的医疗记录，并记录了相关数据。在1305名新生儿中，2.5% （n = 33）发生围产期酸中毒，其中27% （n = 9）发生HIE（轻度2例；中度4例；重度3例）。出生后1小时第一次动脉血气代谢性酸中毒的持续性与HIE显著相关（P < 0.005）。4例中度HIE患儿中3例磁共振成像结果异常，2例重度HIE患儿中2例磁共振成像结果异常。没有轻度或中度HIE患儿发生死亡或残疾，但所有重度HIE患儿均发生死亡或残疾。对足月新生儿进行生化和神经学评估的HIE筛查标准可适用于妊娠33至35周的早产儿。
To determine the frequency of hypoxic-ischemic encephalopathy (HIE) in preterm infants of 33 to 35 weeks’ gestational age on the basis of physiological screening for perinatal acidosis and neurological assessment of encephalopathy and to correlate neurodevelopmental outcomes with brain magnetic resonance imaging findings. This retrospective cohort study included all inborn infants of 33 to 35 weeks’ gestation admitted to the neonatal intensive care unit at Parkland Memorial Hospital with perinatal acidosis from October 2005 to September 2008. Their medical records were reviewed, and pertinent data were recorded. Of 1305 newborns, 2.5% (n = 33) had perinatal acidosis, and 27% (n = 9) of these had HIE (2, mild; 4, moderate; 3, severe). Persistence of metabolic acidosis on the first arterial blood gas obtained in the first hour of age was significantly associated with HIE (P < .005). Magnetic resonance imaging results were abnormal in 3 of 4 infants with moderate HIE and in both survivors with severe HIE. Death or disability occurred in no infants with mild or moderate HIE, but in all infants with severe HIE. Screening criteria for HIE that use biochemical and neurological assessments as performed in term newborns can be applied to preterm infants of 33 to 35 weeks’ gestation.
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影响因子：
48
作者：
Rutherford, Mary;Ramenghi, Luca A.;Edwards, A. David;Brocklehurst, Peter;Halliday, Henry;Levene, Malcolm;Strohm, Brenda;Thoresen, Marianne;Whitelaw, Andrew;Azzopardi, Denis
通讯作者：
Azzopardi, Denis
影响因子：
5.1
作者：
King, TA;Jackson, GL;Laptook, AR
通讯作者：
Laptook, AR
DOI：
10.1016/s0002-9378(85)80205-2
发表时间：
1985-01-01
影响因子：
9.8
作者：
LOW, JA;GALBRAITH, RS;KARCHMAR, EJ
通讯作者：
KARCHMAR, EJ
影响因子：
2.5
作者：
SHANKARAN, S;WOLDT, E;NANDYAL, R
通讯作者：
NANDYAL, R
DOI：
10.1136/bmj.c1471
发表时间：
2010-05-13
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Malin GL;Morris RK;Khan KS
通讯作者：
Khan KS