Diabetic Cardiomyopathy Modelling Using Induced Pluripotent Stem Cell Derived Cardiomyocytes: Recent Advances and Emerging Models.
Diabetic Cardiomyopathy Modelling Using Induced Pluripotent Stem Cell Derived Cardiomyocytes: Recent Advances and Emerging Models.
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DOI：
10.1007/s12015-018-9858-1
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发表时间：
2019-03
影响因子：
4.8
通讯作者：
Sartipy P
中科院分区：
文献类型：
--
作者：
Granéli C;Hicks R;Brolén G;Synnergren J;Sartipy P
过去几十年来，全球糖尿病负担急剧增加，2017年约有400万人死于糖尿病和心血管并发症。糖尿病心肌病是糖尿病的常见并发症，早期表现为舒张功能障碍和左心室肥大，随后进展为收缩功能障碍，最终心力衰竭。准确再现糖尿病心肌病关键过程的体外模型将为研究潜在疾病机制提供有用的工具，以进一步了解该疾病，从而潜在地推进患者的治疗策略。由于其增殖能力和分化潜力，人诱导多能干细胞（iPSC）代表了用于这种模型系统的有吸引力的细胞来源，并且衍生自诱导多能干细胞的心肌细胞已用于建立其他心血管相关疾病模型。在这里，我们回顾了最近取得的进展，并讨论了糖尿病心肌病模型仍需克服的挑战，特别关注基于iPSC的系统。最近的出版物以及本文提供的初步数据证明了产生具有糖尿病表型的心肌细胞的可行性，显示胰岛素抵抗，钙处理受损和肥大。然而，捕获糖尿病心肌细胞的完整代谢和功能表型仍有待完成。本文的在线版本（10.1007/s12015-018-9858-1）包含补充材料，可供授权用户使用。
The global burden of diabetes has drastically increased over the past decades and in 2017 approximately 4 million deaths were caused by diabetes and cardiovascular complications. Diabetic cardiomyopathy is a common complication of diabetes with early manifestations of diastolic dysfunction and left ventricular hypertrophy with subsequent progression to systolic dysfunction and ultimately heart failure. An in vitro model accurately recapitulating key processes of diabetic cardiomyopathy would provide a useful tool for investigations of underlying disease mechanisms to further our understanding of the disease and thereby potentially advance treatment strategies for patients. With their proliferative capacity and differentiation potential, human induced pluripotent stem cells (iPSCs) represent an appealing cell source for such a model system and cardiomyocytes derived from induced pluripotent stem cells have been used to establish other cardiovascular related disease models. Here we review recently made advances and discuss challenges still to be overcome with regard to diabetic cardiomyopathy models, with a special focus on iPSC-based systems. Recent publications as well as preliminary data presented here demonstrate the feasibility of generating cardiomyocytes with a diabetic phenotype, displaying insulin resistance, impaired calcium handling and hypertrophy. However, capturing the full metabolic- and functional phenotype of the diabetic cardiomyocyte remains to be accomplished. The online version of this article (10.1007/s12015-018-9858-1) contains supplementary material, which is available to authorized users.
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DOI：
10.1016/j.bbamcr.2011.01.014
发表时间：
2011-07
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Duncan JG
通讯作者：
Duncan JG
影响因子：
8.2
作者：
Bugger, Heiko;Abel, E. Dale
通讯作者：
Abel, E. Dale
影响因子：
15.9
作者：
GERTZ, EW;WISNESKI, JA;NEESE, RA
通讯作者：
NEESE, RA
影响因子：
4.8
作者：
Chanda, Dipanjan;Oligschlaeger, Yvonne;Neumann, Dietbert
通讯作者：
Neumann, Dietbert
影响因子：
8.8
作者：
Drawnel, Faye M.;Boccardo, Stefano;Iacone, Roberto
通讯作者：
Iacone, Roberto