Filovirus Strategies to Escape Antiviral Responses.
Filovirus Strategies to Escape Antiviral Responses.
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DOI：
10.1007/82_2017_13
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发表时间：
2017
影响因子：
--
通讯作者：
Mühlberger E
中科院分区：
文献类型：
--
作者：
Olejnik J;Hume AJ;Leung DW;Amarasinghe GK;Basler CF;Mühlberger E
本章描述了丝状病毒用于逃避宿主免疫反应的各种策略，重点是先天免疫和细胞死亡途径。由于丝状病毒复制可以被干扰素（IFN）有效地阻断，丝状病毒已经进化出抵消I型IFN诱导和IFN应答信号传导途径的机制。有趣的是，马尔堡病毒和埃博拉病毒使用不同的策略来抑制IFN信号。本章还总结了IFN刺激基因（ISG）在丝状病毒感染中的作用。它们分为三类：限制丝状病毒复制的那些，其激活被丝状病毒抑制的那些，以及对病毒复制没有可测量影响的那些。除了先天免疫外，哺乳动物细胞还进化出了对抗病毒感染的策略，包括诱导细胞死亡和应激反应途径，我们总结了丝状病毒如何与这些途径相互作用的现有知识。最后，本章深入研究了EBOV与髓样树突状细胞和巨噬细胞的相互作用以及相关的炎症反应，当这些细胞感染EBOV时，这些细胞类型之间存在显着差异。总之，我们强调了丝状病毒感染期间宿主-病毒相互作用的多方面性质。
This chapter describes the various strategies filoviruses use to escape host immune responses with a focus on innate immune and cell death pathways. Since filovirus replication can be efficiently blocked by interferon (IFN), filoviruses have evolved mechanisms to counteract both type I IFN induction and IFN response signaling pathways. Intriguingly, marburg- and ebolaviruses use different strategies to inhibit IFN signaling. This chapter also summarizes what is known about the role of IFN-stimulated genes (ISGs) in filovirus infection. These fall into three categories: those that restrict filovirus replication, those whose activation is inhibited by filoviruses, and those that have no measurable effect on viral replication. In addition to innate immunity, mammalian cells have evolved strategies to counter viral infections, including the induction of cell death and stress response pathways, and we summarize our current knowledge of how filoviruses interact with these pathways. Finally, this chapter delves into the interaction of EBOV with myeloid dendritic cells and macrophages and the associated inflammatory response, which differs dramatically between these cell types when they are infected with EBOV. In summary, we highlight the multifaceted nature of the host-viral interactions during filoviral infections.
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影响因子：
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作者：
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通讯作者：
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