Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing.
Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing.
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DOI：
10.1371/journal.pone.0020294
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Ray-Coquard I
中科院分区：
文献类型：
--
作者：
Ducimetière F;Lurkin A;Ranchère-Vince D;Decouvelaere AV;Péoc'h M;Istier L;Chalabreysse P;Muller C;Alberti L;Bringuier PP;Scoazec JY;Schott AM;Bergeron C;Cellier D;Blay JY;Ray-Coquard I
肉瘤和肉瘤亚型的确切总体发病率尚不清楚。目前基于人群的研究的目的是根据对病例的集中病理学审查，确定拥有 600 万居民的欧洲地区（罗纳-阿尔卑斯）的这种发病率。从2005年3月到2007年2月，前瞻性地收集了罗讷-阿尔卑斯地区158名病理学家的病理报告和肿瘤块。所有诊断或疑似肉瘤病例均被收集、集中审查、检查分子改变并根据 2002 年世界卫生组织分类进行分类。在研究期间筛查的 1287 名患者中，748 名患者符合研究纳入标准。总体粗发病率和世界年龄标准化发病率分别为每 10 万人/年 6.2 例和 4.8 例/年。软组织肉瘤、内脏肉瘤和骨肉瘤的发病率分别为每10万人3.6、2.0和0.6。最常见的组织学亚型是胃肠道间质瘤（18%；1.1/100,000）、未分类肉瘤（16%；1/100,000）、脂肪肉瘤（15%；0.9/100,000）和平滑肌肉瘤（11%；0.7/100,000）。观察到的肉瘤发病率高于预期。这项研究是对肉瘤组织学和分子亚型粗发病率的首次详细调查。
The exact overall incidence of sarcoma and sarcoma subtypes is not known. The objective of the present population-based study was to determine this incidence in a European region (Rhone-Alpes) of six million inhabitants, based on a central pathological review of the cases. From March 2005 to February 2007, pathology reports and tumor blocks were prospectively collected from the 158 pathologists of the Rhone-Alpes region. All diagnosed or suspected cases of sarcoma were collected, reviewed centrally, examined for molecular alterations and classified according to the 2002 World Health Organization classification. Of the 1287 patients screened during the study period, 748 met the criteria for inclusion in the study. The overall crude and world age-standardized incidence rates were respectively 6.2 and 4.8 per 100,000/year. Incidence rates for soft tissue, visceral and bone sarcomas were respectively 3.6, 2.0 and 0.6 per 100,000. The most frequent histological subtypes were gastrointestinal stromal tumor (18%; 1.1/100,000), unclassified sarcoma (16%; 1/100,000), liposarcoma (15%; 0.9/100,000) and leiomyosarcoma (11%; 0.7/100,000). The observed incidence of sarcomas was higher than expected. This study is the first detailed investigation of the crude incidence of histological and molecular subtypes of sarcomas.
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影响因子：
45.3
作者：
Corless, CL;Fletcher, JA;Heinrich, MC
通讯作者：
Heinrich, MC
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
45.3
作者：
Ferrari, A;Casanova, M;Fossati-Bellani, F
通讯作者：
Fossati-Bellani, F
影响因子：
0.9
作者：
Colonna, M.;Bossard, N.;Grosclaude, P.
通讯作者：
Grosclaude, P.
影响因子：
3.8
作者：
Eyre, Rachel;Feltbower, Richard G.;McNally, Richard J. Q.
通讯作者：
McNally, Richard J. Q.