Audiovisual task switching rapidly modulates sound encoding in mouse auditory cortex.
Audiovisual task switching rapidly modulates sound encoding in mouse auditory cortex.
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DOI：
10.7554/elife.75839
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发表时间：
2022-08-18
期刊：
影响因子：
7.7
通讯作者：
Hasenstaub, Andrea R.
中科院分区：
文献类型：
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作者：
Morrill, Ryan J.;Bigelow, James;DeKloe, Jefferson;Hasenstaub, Andrea R.
在日常行为中，感觉系统不断竞争注意力资源，但模态选择性注意的细胞和回路水平机制仍然没有得到很大程度的研究。在视听（AV）注意转移任务中，我们在小鼠听觉皮层（AC）进行了跨层记录。出席AV流中的声音元素减少了预刺激和刺激诱发的尖峰活动，主要是在深层神经元和神经元没有spectrotemporal调谐。尽管减少尖峰，刺激解码器的准确性得到保留，这表明提高了声音编码效率。同样，任务无关的映射刺激在试验间隔期间诱发较少的尖峰，而不损害刺激编码，表明注意力调制广义超越训练刺激。重要的是，尖峰减少预测试验到试验的行为准确性在听觉注意，但不是视觉注意。总之，这些研究结果表明，听觉注意力通过过滤AC中与声音无关的背景活动来促进声音辨别，并且最深的皮层层作为整合非模态上下文信息的枢纽。
In everyday behavior, sensory systems are in constant competition for attentional resources, but the cellular and circuit-level mechanisms of modality-selective attention remain largely uninvestigated. We conducted translaminar recordings in mouse auditory cortex (AC) during an audiovisual (AV) attention shifting task. Attending to sound elements in an AV stream reduced both pre-stimulus and stimulus-evoked spiking activity, primarily in deep-layer neurons and neurons without spectrotemporal tuning. Despite reduced spiking, stimulus decoder accuracy was preserved, suggesting improved sound encoding efficiency. Similarly, task-irrelevant mapping stimuli during inter-trial intervals evoked fewer spikes without impairing stimulus encoding, indicating that attentional modulation generalized beyond training stimuli. Importantly, spiking reductions predicted trial-to-trial behavioral accuracy during auditory attention, but not visual attention. Together, these findings suggest auditory attention facilitates sound discrimination by filtering sound-irrelevant background activity in AC, and that the deepest cortical layers serve as a hub for integrating extramodal contextual information.
DOI：
10.1016/j.crneur.2022.100040
发表时间：
2022
期刊：
Current research in neurobiology
影响因子：
--
作者：
Bigelow, James;Morrill, Ryan J;Olsen, Timothy;Hasenstaub, Andrea R
通讯作者：
Hasenstaub, Andrea R