The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in myalgic encephalomyelitis/chronic fatigue syndrome: A meta-analysis of public DNA methylation and gene expression data.
The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in myalgic encephalomyelitis/chronic fatigue syndrome: A meta-analysis of public DNA methylation and gene expression data.
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DOI：
10.1016/j.heliyon.2021.e07665
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发表时间：
2021-08
期刊：
影响因子：
4
通讯作者：
Sepúlveda N
中科院分区：
文献类型：
--
作者：
Malato J;Sotzny F;Bauer S;Freitag H;Fonseca A;Grabowska AD;Graça L;Cordeiro C;Nacul L;Lacerda EM;Castro-Marrero J;Scheibenbogen C;Westermeier F;Sepúlveda N
肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)患者在病程中经常报告高频率的病毒感染和流感样症状。鉴于这一报道与在疾病中观察到的不同免疫异常和改变的基因表达谱相一致，我们旨在回答这些患者中是否也改变了SARS-CoV-2的主要细胞进入受体-人血管紧张素转换酶2(ACE2)的表达。特别是，血管紧张素转换酶2的低表达可能预示着发生新冠肺炎的高风险。然后，我们对外周血单核细胞和相关亚群中CpG DNA甲基化和该酶及其同源ACE蛋白的基因表达的公开数据进行了荟萃分析。我们发现ME/CFS患者ACE基因座的四个CpG探针(cg09920557、cg19802564、cg21094739和cg10468385)以及ACE2基因启动子区的另一个探针(Cg08559914)的甲基化水平降低。我们还发现，与健康对照组相比，患者ACE2的表达减少，但ACE的表达没有下降。因此，在新收集的数据中，有证据表明，患者中ACE2表达低于检测限值的样本比例明显高于健康对照组。总体而言，ME/CFS患者可能面临更高的新冠肺炎风险，如果是这样的话，他们应该被公共卫生当局视为优先接种疫苗的群体。为了进一步支持这一结论，建议对其他人类细胞进入受体和细胞类型进行类似的研究，即病毒靶向的那些细胞。肌痛性脑脊髓炎/慢性疲劳综合征，SARS-CoV-2，ACE2，基因表达，DNA甲基化
People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often report a high frequency of viral infections and flu-like symptoms during their disease course. Given that this reporting agrees with different immunological abnormalities and altered gene expression profiles observed in the disease, we aimed at answering whether the expression of the human angiotensin-converting enzyme 2 (ACE2), the major cell entry receptor for SARS-CoV-2, is also altered in these patients. In particular, a low expression of ACE2 could be indicative of a high risk of developing COVID-19. We then performed a meta-analysis of public data on CpG DNA methylation and gene expression of this enzyme and its homologous ACE protein in peripheral blood mononuclear cells and related subsets. We found that patients with ME/CFS have decreased methylation levels of four CpG probes in the ACE locus (cg09920557, cg19802564, cg21094739, and cg10468385) and of another probe in the promoter region of the ACE2 gene (cg08559914). We also found a decreased expression of ACE2 but not of ACE in patients when compared to healthy controls. Accordingly, in newly collected data, there was evidence for a significant higher proportion of samples with an ACE2 expression below the limit of detection in patients than healthy controls. Altogether, patients with ME/CFS can be at a higher COVID-19 risk and, if so, they should be considered a priority group for vaccination by public health authorities. To further support this conclusion, similar research is recommended for other human cell entry receptors and cell types, namely, those cells targeted by the virus. Myalgic encephalomyelitis/chronic fatigue syndrome, SARS-CoV-2, ACE2, Gene expression, DNA methylation
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DOI：
10.1080/03610918.2014.957839
发表时间：
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影响因子：
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