The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy.
The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy.
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小密 LDL 颗粒/大浮力 LDL 颗粒比率与妊娠期葡萄糖代谢状态相关
DOI：
10.1186/s12944-017-0627-y
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发表时间：
2017-12-14
影响因子：
4.5
通讯作者：
Chen D
中科院分区：
文献类型：
--
作者：
Chen Y;Du M;Xu J;Chen D
背景脂蛋白亚组分颗粒谱可用于改善心血管疾病风险的临床评估，有助于早期发现致动脉粥样硬化性血脂异常。妊娠期糖尿病的血脂改变已被广泛研究，但结果一直不一致。在这里，我们调查了血清脂蛋白亚组分颗粒水平及其与妊娠期糖代谢状态的关系，在pregnancy.MethodsTwenty-eight妊娠期糖尿病和56例妊娠期糖耐量正常的孕妇相匹配的体重指数参加了这项研究。我们评估了空腹血脂浓度和脂蛋白亚组分颗粒水平在参与者之间的24和28 weeks pregnancy.ResultsThe水平的低密度脂蛋白（LDL）胆固醇显着降低妊娠期糖尿病的妇女比那些与正常的葡萄糖耐量，但甘油三酯和高密度脂蛋白（HDL）胆固醇水平的两组是相似的。脂蛋白颗粒分析显示，极低密度脂蛋白（VLDL）颗粒数和小密度LDL颗粒/大浮力LDL颗粒（sdLDL-P/lbLDL-P）比值在妊娠期糖尿病组显著高于糖耐量正常组（P= 0.013和P = 0.015）。多因素分析显示，校正孕妇年龄、妊娠期体重增加、BMI和LDL胆固醇后，空腹血糖与sdLDL-P/lbLDL-P比值仍呈独立正相关（标准化Beta = 0.214，P = 0.029）。
BackgroundThe lipoprotein subfraction particle profile can be used to improve clinical assessments of cardiovascular disease risk and contribute to early detection of atherogenic dyslipidemia. Lipid alterations in gestational diabetes have been extensively studied, but the results have been inconsistent. Here, we investigated serum lipoprotein subfraction particle levels and their association with glucose metabolic status in pregnancy.MethodsTwenty-eight pregnant women with gestational diabetes and 56 pregnant women with normal glucose tolerance matched for body mass index were enrolled in this study. We assessed fasting serum lipid concentrations and lipoprotein subfraction particle levels in participants between 24 and 28 weeks of gestation.ResultsThe level of low-density lipoprotein (LDL) cholesterol was significantly lower in women with gestational diabetes than in those with normal glucose tolerance, but the triglyceride and high-density lipoprotein (HDL) cholesterol levels of the two groups were similar. Lipoprotein particle analysis showed that very-low-density lipoprotein (VLDL) particle number and the small dense LDL particle/large buoyant LDL particle (sdLDL-P/lbLDL-P) ratio were significantly higher in women with gestational diabetes than in those with normal glucose tolerance (P= 0.013 andP= 0.015, respectively). In multivariate analysis, fasting glucose was independently and positively associated with sdLDL-P/lbLDL-P ratio even after adjustment for maternal age, gestational weight gain, BMI and LDL cholesterol (standardized Beta = 0.214,P= 0.029).ConclusionsThe sdLDL-P/lbLDL-P ratio is higher in GDM compared with non-diabetic pregnant women, and positively and independently associated with fasting glucose in pregnant women.
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影响因子：
6.1
作者：
Silva-Zolezzi I;Samuel TM;Spieldenner J
通讯作者：
Spieldenner J
影响因子：
4.4
作者：
Stitziel NO
通讯作者：
Stitziel NO
影响因子：
168.9
作者：
Peters, RK;Kjos, SL;Buchanan, TA
通讯作者：
Buchanan, TA
影响因子：
7.1
作者：
Asemi, Zatollah;Hashemi, Teibeh;Esmaillzadeh, Ahmad
通讯作者：
Esmaillzadeh, Ahmad
影响因子：
2.1
作者：
Qiu, C.;Rudra, C.;Williams, M. A.
通讯作者：
Williams, M. A.