Rule-based model of vein graft remodeling.
Rule-based model of vein graft remodeling.
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DOI：
10.1371/journal.pone.0057822
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Tran-Son-Tay R
中科院分区：
文献类型：
--
作者：
Hwang M;Garbey M;Berceli SA;Wu R;Jiang Z;Tran-Son-Tay R
当将静脉段植入动脉系统用于动脉旁路移植术时，通过壁增厚和扩张来实现对动脉系统的较高压力和流量的适应。已经发现这些早期重塑事件与局部血流动力学力（例如剪切应力和壁张力）密切相关，并且被认为是后期静脉移植物失败的基础。为了进一步我们的细胞和细胞外的相互作用，导致组织结构的全球变化的机械理解，基于规则的建模方法是通过这些分子和细胞活动的行为的基本规则的应用程序。在本方法中，选择平滑肌细胞（SMC）、细胞外基质（ECM）和单核细胞作为占据包括发育中的静脉移植物内膜的网格系统的元素的三种组分。基于从体内实验中提取的数据开发细胞行为的概率。在每个时间步，计算各种概率并将其应用于SMC和ECM元件以确定它们的下一个物理状态和行为。一维和二维模型的开发，以测试和验证的计算方法。评估了单核细胞浸润的重要性以及增加细胞外基质沉积的相关作用，发现其是模型开发中的重要组成部分。使用一组独立的实验进行最终模型验证，其中对内膜生长的模型预测进行评价，对照从复杂的几何形状获得的实验数据和移植物中部局灶性狭窄提供的剪切应力模式，其中模拟结果显示与实验数据的良好一致性。
When vein segments are implanted into the arterial system for use in arterial bypass grafting, adaptation to the higher pressure and flow of the arterial system is accomplished thorough wall thickening and expansion. These early remodeling events have been found to be closely coupled to the local hemodynamic forces, such as shear stress and wall tension, and are believed to be the foundation for later vein graft failure. To further our mechanistic understanding of the cellular and extracellular interactions that lead to global changes in tissue architecture, a rule-based modeling method is developed through the application of basic rules of behaviors for these molecular and cellular activities. In the current method, smooth muscle cell (SMC), extracellular matrix (ECM), and monocytes are selected as the three components that occupy the elements of a grid system that comprise the developing vein graft intima. The probabilities of the cellular behaviors are developed based on data extracted from in vivo experiments. At each time step, the various probabilities are computed and applied to the SMC and ECM elements to determine their next physical state and behavior. One- and two-dimensional models are developed to test and validate the computational approach. The importance of monocyte infiltration, and the associated effect in augmenting extracellular matrix deposition, was evaluated and found to be an important component in model development. Final model validation is performed using an independent set of experiments, where model predictions of intimal growth are evaluated against experimental data obtained from the complex geometry and shear stress patterns offered by a mid-graft focal stenosis, where simulation results show good agreements with the experimental data.
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影响因子：
4.3
作者：
Berceli, SA;Davies, MG;Clowes, AW
通讯作者：
Clowes, AW
DOI：
10.1152/ajpheart.00268.2009
发表时间：
2009-10-01
影响因子：
4.8
作者：
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影响因子：
2.2
作者：
Berceli, Scott A.;Jiang, Zhihua;Ozaki, C. Keith
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Ozaki, C. Keith
DOI：
10.1016/0735-1097(96)00206-9
发表时间：
1996-09-01
影响因子：
24
作者：
FitzGibbon, GM;Kafka, HP;Burton, JR
通讯作者：
Burton, JR
DOI：
10.1152/ajpheart.00760.2003
发表时间：
2004-01-01
影响因子：
4.8
作者：
Jiang, ZH;Wu, LZ;Berceli, SA
通讯作者：
Berceli, SA