Geranylgeranylation promotes proliferation, migration and invasion of gastric cancer cells through the YAP signaling pathway.
Geranylgeranylation promotes proliferation, migration and invasion of gastric cancer cells through the YAP signaling pathway.
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香叶基香叶基化通过YAP信号通路促进胃癌细胞的增殖、迁移和侵袭。
DOI：
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Qiong Lin
中科院分区：
文献类型：
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作者：
Jing Wei;Ke Peng;Jun Zhu;Lincui Wang;Tiantian Han;Aiqin Sun;Genbao Shao;Hanqing Liu;Wannian Yang;Qiong Lin
香叶酰化（gg酰化）是信号蛋白的脂质修饰过程。目前，对胃癌细胞增殖和迁移的gg酰化信号知之甚少。在本报告中，我们发现甲羟戊酸途径抑制剂阿托伐他汀和香叶基香叶基转移酶I抑制剂GGTI-298对gg酰化的抑制会损害胃癌AGS细胞的增殖和迁移。在寻找信号通路的过程中，我们通过检测其已知靶基因CYR61和CTGF的mRNA水平和向细胞核的易位来评估YAP （hippo通路的转录激活因子和下游效应因子）被gg酰化抑制。shrna敲低YAP对胃癌AGS细胞的增殖和迁移的影响与抑制gg化作用相似，提示gg化信号通过激活YAP促进胃癌细胞的增殖和迁移。我们的研究为胃癌提供了一条潜在的新的靶向治疗途径。
Geranylgeranylation (GGylation) is a lipid modification process of signaling proteins. Currently, very little is known about the GGylation signaling for gastric cancer cell proliferation and migration. In this report, we found that inhibition of GGylation by the mevalonate pathway inhibitor atorvastatin and the geranylgeranyltransferase I inhibitor GGTI-298 impairs proliferation and migration of the gastric cancer AGS cells. During searching the signaling pathway for the effect, we observed that YAP, a transcription activator and downstream effector of the hippo pathway, was suppressed by inhibition of GGylation, as evaluated by detection of the mRNA level of its known target genes CYR61 and CTGF and translocation to nuclei. Knockdown of YAP by shRNAs produced a similar effect on proliferation and migration of gastric cancer AGS cells to that of GGylation inhibition, suggesting that GGylation signaling promotes gastric cancer cell proliferation and migration by activation of YAP. Our studies provide a potential new therapeutic targeting pathway for gastric cancer.
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影响因子：
6.5
作者：
Patrick J. Casey
通讯作者：
Patrick J. Casey
影响因子：
2.9
作者：
Xiao-dan Wu;K. Zeng;Fang-Qin Xue;Jinhua Chen;Yan-qing Chen
通讯作者：
Xiao-dan Wu;K. Zeng;Fang-Qin Xue;Jinhua Chen;Yan-qing Chen
影响因子：
8.8
作者：
Qiao, Yiting;Chen, Jianxiang;Sudol, Marius
通讯作者：
Sudol, Marius
DOI：
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发表时间：
2003-11
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
Niels W.C.J. Van de Donk;D. Schotte;M. Kamphuis;A. V. van Marion;B. van Kessel;A. Bloem;H. Lokhorst
通讯作者：
Niels W.C.J. Van de Donk;D. Schotte;M. Kamphuis;A. V. van Marion;B. van Kessel;A. Bloem;H. Lokhorst
DOI：
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发表时间：
1992-07
期刊：
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
影响因子：
--
作者：
R. Khosravi‐Far;A. Cox;K. Kato;C. Der
通讯作者：
R. Khosravi‐Far;A. Cox;K. Kato;C. Der