Early development of the cochlea of the common marmoset, a non-human primate model.
Early development of the cochlea of the common marmoset, a non-human primate model.
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DOI：
10.1186/s13064-022-00162-8
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发表时间：
2022-05-07
影响因子：
3.6
通讯作者：
Ozawa, Hiroyuki
中科院分区：
文献类型：
--
作者：
Hosoya, Makoto;Fujioka, Masato;Okahara, Junko;Yoshimatsu, Sho;Okano, Hideyuki;Ozawa, Hiroyuki
精细的耳蜗发育对听力至关重要。由于使用早期人类胎儿样本的困难，我们关于耳蜗发育的大部分知识都是从啮齿动物中获得的。然而，在啮齿动物和人类之间的耳蜗发育的几个物种间的差异已被报道。为了弥合这些差异，我们研究了一种非人类灵长类模式动物——普通狨猴（Callithrix jacchus）的早期听觉发育。我们检查了20个参与早期耳蜗发育的基因，并描述了形态发生的关键发育步骤，这些步骤在啮齿动物和狨猴之间有所不同。结果显示，涉及前感觉上皮规格的几个关键基因在种间表现出更高的差异，这表明灵长类动物的毛细胞谱系获得的分子过程与啮齿类动物有很大不同。我们还观察到，灵长类动物的耳蜗发育速度比啮齿类动物慢三倍。我们的数据为灵长类动物和人类早期耳蜗发育提供了新的见解，并暗示由于细胞命运决定程序内在的物种间差异，用于操纵啮齿动物耳蜗感觉细胞的程序不能直接用于灵长类细胞的研究。
Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents. However, several inter-species differences in cochlear development between rodents and humans have been reported. To bridge these differences, we investigated early otic development of a non-human primate model animal, the common marmoset (Callithrix jacchus). We examined 20 genes involved in early cochlear development and described the critical developmental steps for morphogenesis, which have been reported to vary between rodents and marmosets. The results revealed that several critical genes involved in prosensory epithelium specifications showed higher inter-species differences, suggesting that the molecular process for hair cell lineage acquisition in primates differs considerably from that of rodents. We also observed that the tempo of cochlear development was three times slower in the primate than in rodents. Our data provide new insights into early cochlear development in primates and humans and imply that the procedures used for manipulating rodent cochlear sensory cells cannot be directly used for the research of primate cells due to the intrinsic inter-species differences in the cell fate determination program.
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DOI：
10.1111/febs.15341
发表时间：
2021-01
期刊：
The FEBS journal
影响因子：
--
作者：
Hosoya M;Fujioka M;Murayama AY;Okano H;Ogawa K
通讯作者：
Ogawa K
DOI：
10.1242/dev.164368
发表时间：
2018-06-26
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Ebisuya M;Briscoe J
通讯作者：
Briscoe J
DOI：
10.1073/pnas.0808175105
发表时间：
2008-11-25
影响因子：
11.1
作者：
Dabdoub, Alain;Puligilla, Chandrakala;Kelley, Matthew W.
通讯作者：
Kelley, Matthew W.
影响因子：
4.5
作者：
Kiernan AE;Xu J;Gridley T
通讯作者：
Gridley T
影响因子：
3.5
作者：
Hosoya M;Fujioka M;Murayama AY;Ogawa K;Okano H;Ozawa H
通讯作者：
Ozawa H