What does time mean in development?
What does time mean in development?
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DOI：
10.1242/dev.164368
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发表时间：
2018-06-26
期刊：
影响因子：
--
通讯作者：
Briscoe J
中科院分区：
文献类型：
--
作者：
Ebisuya M;Briscoe J
生物学是动态的。时间尺度从疯狂的亚秒级离子通量和酶促反应到冰河时期数百万年的进化变化。在这个范围的中间是我们通常在发育中研究的过程：细胞分裂和分化、基因表达、细胞-细胞信号传导和形态发生。但是，是什么设定了发展事件的节奏并管理了发展事件的顺序呢？物种之间的顺序和节奏不同吗？多个事件的顺序是如何协调的？在这里，我们讨论了时间对胚胎发育的重要性，强调了全球和细胞自主控制的必要性。成像和基因组工程的新试剂和工具，结合体外培养，开始为发育时间的起源和机制提供新的视角和分子洞察力。总结：是什么决定了发展事件的节奏和顺序？成像、基因组工程和体外培养方面的新试剂和新技术正开始为了解发育时间的机制提供新的见解。
Biology is dynamic. Timescales range from frenetic sub-second ion fluxes and enzymatic reactions to the glacial millions of years of evolutionary change. Falling somewhere in the middle of this range are the processes we usually study in development: cell division and differentiation, gene expression, cell-cell signalling, and morphogenesis. But what sets the tempo and manages the order of developmental events? Are the order and tempo different between species? How is the sequence of multiple events coordinated? Here, we discuss the importance of time for developing embryos, highlighting the necessity for global as well as cell-autonomous control. New reagents and tools in imaging and genomic engineering, combined with in vitro culture, are beginning to offer fresh perspectives and molecular insight into the origin and mechanisms of developmental time. Summary: What sets the tempo and manages the order of developmental events? New reagents and techniques in imaging, genomic engineering and in vitro culture are beginning to offer insight into the mechanisms of developmental time.
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影响因子：
11.8
作者：
Grosskortenhaus, R;Pearson, BJ;Doe, CQ
通讯作者：
Doe, CQ
DOI：
10.1007/978-1-4939-2848-4_10
发表时间：
2015-01-01
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Ben-Nun, Inbar Friedrich;Montague, Susanne C;Loring, Jeanne F
通讯作者：
Loring, Jeanne F
影响因子：
64.5
作者：
Fiddes IT;Lodewijk GA;Mooring M;Bosworth CM;Ewing AD;Mantalas GL;Novak AM;van den Bout A;Bishara A;Rosenkrantz JL;Lorig-Roach R;Field AR;Haeussler M;Russo L;Bhaduri A;Nowakowski TJ;Pollen AA;Dougherty ML;Nuttle X;Addor MC;Zwolinski S;Katzman S;Kriegstein A;Eichler EE;Salama SR;Jacobs FMJ;Haussler D
通讯作者：
Haussler D
影响因子：
64.8
作者：
Gaspard, Nicolas;Bouschet, Tristan;Vanderhaeghen, Pierre
通讯作者：
Vanderhaeghen, Pierre
影响因子：
16.6
作者：
Boone, Emilie;Colombani, Julien;Andersen, Ditte S.;Leopold, Pierre
通讯作者：
Leopold, Pierre