Cerebral Microbleeds in Patients with Parkinson's Disease and Dementia with Lewy Bodies: Comparison Using Magnetic Resonance Imaging and 99 mTc-ECD SPECT Subtraction Imaging.
Cerebral Microbleeds in Patients with Parkinson's Disease and Dementia with Lewy Bodies: Comparison Using Magnetic Resonance Imaging and 99 mTc-ECD SPECT Subtraction Imaging.
复制标题
帕金森病和路易体痴呆患者的脑微出血：使用磁共振成像和 99 mTc-ECD SPECT 减影成像进行比较。
DOI：
10.3233/jad-201495
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
K. Abe
中科院分区：
文献类型：
--
作者：
M. Takemoto;T. Yamashita;Y. Ohta;Koh Tadokoro;Y. Omote;R. Morihara;K. Abe
背景
帕金森病 (PD) 或路易体痴呆 (DLB) 患者的脑微出血 (CMB) 尚未得到充分研究。
目标
本研究旨在找出 PD 和 DLB 之间 CMB 总数、患病率和常见位置的差异，并评估这两种疾病的 99 mTc-ECD SPECT 减影图像。
方法
我们使用脑磁共振成像 (MRI) 和 99 mTc-ECD SPECT 减影成像检查了 112 名 PD 患者（53 名男性和 59 名女性；年龄：77.4±3.6 岁）和 28 名年龄匹配的 DLB 患者（15 名男性和 13 名女性；年龄：77.1±6.7 岁）。
结果
DLB患者的CMB总数（41.2%）高于PD患者（11.5%），且前者的患病率（0.7±1.1）显着高于后者（0.2±0.5，p < 0.05）。优势比为 5.4（95% 置信区间 [CI]：1.7-17.4）。此外，CMB 通常位于 PD 患者的基底神经节（87 名患者中的 6 名），但 DLB 患者的枕叶（17 名患者中的 8 名）。 99 mTc-ECD SPECT 减影成像显示，CMB 阳性 DLB 患者的后扣带回脑血流量低于 CMB 阳性 PD 患者；此外，与 CMB 阴性 DLB 患者相比，CMB 阳性 DLB 患者双侧基底节和中脑的脑血流量较低。
结论
枕叶葡萄糖代谢降低可能与 DLB 患者枕叶 CMB 相关。
BACKGROUND
Cerebral microbleeds (CMBs) in patients with Parkinson's disease (PD) or dementia with Lewy bodies (DLB) have not been adequately studied.
OBJECTIVE
This study aims to find a difference in the total number, prevalence, and common locations of CMBs between PD and DLB and evaluate 99 mTc-ECD SPECT subtraction images of these two diseases.
METHODS
We examined 112 patients with PD (53 males and 59 females; age: 77.4±3.6 years) and 28 age-matched patients with DLB (15 males and 13 females; age: 77.1±6.7 years) using brain magnetic resonance imaging (MRI) and 99 mTc-ECD SPECT subtraction imaging.
RESULTS
The total number of CMBs was higher in patients with DLB (41.2%) than in those with PD (11.5%), and the prevalence was significantly higher in the former (0.7±1.1) than the latter (0.2±0.5, p < 0.05). The odds ratio was 5.4 (95% confidence interval [CI]: 1.7-17.4). Furthermore, CMBs were commonly located in the basal ganglia of patients with PD (6 out of 87 patients) but in the occipital lobe of patients with DLB (8 out of 17 patients). 99 mTc-ECD SPECT subtraction imaging indicated lower cerebral blood flow in the posterior cingulate gyrus among the patients with CMB-positive DLB than among those with CMB-positive PD; additionally, the cerebral blood flow was lower in the bilateral basal ganglia and midbrain among patients with CMB-positive DLB compared to those with CMB-negative DLB.
CONCLUSION
A reduction in occipital glucose metabolism may be related to CMBs in the occipital lobe of patients with DLB.
影响因子：
5
作者：
FAZEKAS, F;CHAWLUK, JB;ZIMMERMAN, RA
通讯作者：
ZIMMERMAN, RA