Examination of alcoholics by computed tomographic (CT) scans: a critical review.
Examination of alcoholics by computed tomographic (CT) scans: a critical review.
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通过计算机断层扫描（CT）扫描对酗酒者进行检查：批判性评论。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
D. Wilkinson
中科院分区：
文献类型：
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作者：
D. Wilkinson
神经放射学研究一致表明，酗酒者的大脑皮层，脑室和小脑结构的形态异常，提示脑萎缩。这种萎缩与心理测试表现受损的相关性很弱。由于正常衰老过程中也会出现脑萎缩和智力损伤，因此有必要将酗酒者与年龄匹配的对照组进行比较。目前尚不清楚酒精相关性脑萎缩和智力障碍是否是饮酒前的状况或仅间接相关的状况（如头部创伤或其他相关疾病）的结果。定量的酒精-萎缩剂量-反应关系和戒酒后萎缩和功能损害的部分逆转将支持直接酒精毒性。由于神经放射学研究中固有的方法学困难，关于酗酒者异常的确切发病机制的数据尚未产生。这种研究的设计可以改进，以增加阐明脑萎缩原因的可能性。
Neuroradiological studies have consistently demonstrated that alcoholics have morphological abnormalities of cortical, ventricular, and cerebellar structures suggesting brain atrophy. This atrophy is weakly correlated with impaired psychological test performance. Because brain atrophy and intellectual impairment can also be found in normal aging it is necessary to compare alcoholics with age-matched control subjects. It is currently unknown if alcohol-associated brain atrophy and intellectual impairment are the result of conditions preceding alcohol consumption or conditions only indirectly related such as head trauma or other associated diseases. Direct alcohol toxicity would be supported by quantitative alcohol-atrophy dose-response relationships and by a partial reversal of atrophy and functional impairment following abstinence from alcohol. Because of methodological difficulties inherent in neuroradiological research, data on the exact pathogenesis of abnormalities in alcoholics have not been produced. The design of such studies can be improved to increase the probability that the causes of brain atrophy will be elucidated.
酗酒者认知功能障碍与脑损伤之间的关系：因果关系、交互作用还是附带现象？
DOI：
10.1111/j.1530-0277.1981.tb04906.x
发表时间：
1981
期刊：
Alcoholism, clinical and experimental research
影响因子：
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作者：
Parsons,OA;Leber,WR
通讯作者：
Leber,WR