Emerging technologies for point-of-care CD4 T-lymphocyte counting.

Emerging technologies for point-of-care CD4 T-lymphocyte counting.
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DOI:
10.1016/j.tibtech.2011.06.015
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发表时间:
2012-01
影响因子:
17.3
通讯作者:
Cheng, Xuanhong
Cheng, Xuanhong
中科院分区:
工程技术1区
文献类型:
--
作者:
Boyle, David S.;Hawkins, Kenneth R.;Steele, Matthew S.;Singhal, Mitra;Cheng, Xuanhong

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A CD4 T-lymphocyte count determines eligibility for antiretroviral therapy (ART) with patients recently diagnosed with HIV and also monitors the efficacy of ART treatment thereafter. ART slows the progression of HIV to AIDS. In the developing world, CD4 tests are often performed in centralized laboratories, typically in urban areas. The expansion of ART programs into rural areas has created a need for rapid CD4 counting as logistical barriers can delay the timely dissemination of test results and affect patient care through delay in intervention or loss of follow-up care. CD4 measurement at the point-of-care (POC) in rural areas could help facilitating ART and monitoring of treatment. This review highlights recent technology developments with applications towards determining CD4 counts at the POC.
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