Patterned resonance plasmonic microarrays for high-performance SPR imaging.
Patterned resonance plasmonic microarrays for high-performance SPR imaging.
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DOI:
10.1021/ac200190b
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发表时间:
2011-04-15
影响因子:
7.4
通讯作者:
Cheng, Quan
中科院分区:
文献类型:
--
作者:
Abbas, Abdennour;Linman, Matthew J.;Cheng, Quan
We report a novel optical platform based on SPR generation and confinement inside a defined 3-dimensional microwell geometry that leads to background resonance-free SPR images. The array shows an exceptionally high signal-to-noise ratio (S/N>80) for imaging analysis and subnanometric thickness resolution. An angular sensitivity of 1 degree/0.01 RIU has been achieved and the signal to background ratio (S/B) improves to 20, one order of magnitude higher than best literature results. The design proves effective for probing supported lipid membrane arrays in real time with a thickness resolution of 0.24 nm and allows for imaging analysis of microfluidic circuits where resonant spots are separated by only one pixel (~ 7 μm). The high image quality and unique chip geometry open up new avenues for array screening and biomicrofluidics using SPRi detection.
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