Advances in repairing the degenerate retina by rod photoreceptor transplantation.
Advances in repairing the degenerate retina by rod photoreceptor transplantation.
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DOI：
10.1016/j.biotechadv.2014.01.001
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发表时间：
2014-03
影响因子：
16
通讯作者：
Pearson, Rachael A.
中科院分区：
文献类型：
--
作者：
Pearson, Rachael A.
关键词：
尽管病因非常不同，但年龄相关性黄斑变性（AMD）和大多数遗传性视网膜疾病最终以相同的最终共同途径，即光敏感性光感受器的丧失而告终。临床治疗方法很少，没有一种可以逆转视力丧失。通过移植的光感受器替代被提议作为适用于所有变性的广泛治疗策略。在过去的十年中，在这一领域取得了一些具有里程碑意义的成就，这些成就共同为继续研究感光细胞替代策略提供了强有力的理由。其中包括通过在患有先天性静止性夜盲症的小鼠中进行视杆细胞移植来恢复视力的原理证明，以及干细胞生物学的进展，这些进展导致了胚胎干细胞在体外产生完整的光学结构。后者代表了产生合适的和可再生的供体细胞以实现前者的巨大潜力。然而，随着我们将这些技术转化为临床应用，退化的受体视网膜环境仍然存在必须解决的挑战。
Despite very different aetiologies, age-related macular degeneration (AMD) and most inherited retinal disorders culminate in the same final common pathway, loss of the light-sensitive photoreceptors. There are few clinical treatments and none can reverse the loss of vision. Photoreceptor replacement by transplantation is proposed as a broad treatment strategy applicable to all degenerations. The past decade has seen a number of landmark achievements in this field, which together provide strong justification for continuing investigation into photoreceptor replacement strategies. These include proof of principle for restoring vision by rod-photoreceptor transplantation in mice with congenital stationary night blindness and advances in stem cell biology, which have led to the generation of complete optic structures in vitro from embryonic stem cells. The latter represents enormous potential for generating suitable and renewable donor cells with which to achieve the former. However, there are still challenges presented by the degenerating recipient retinal environment that must be addressed as we move to translating these technologies towards clinical application.
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DOI：
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发表时间：
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影响因子：
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