Aqueous Humor Cytokine Levels in Diabetic Macular Edema Patients with Cotton-Wool Spots
Aqueous Humor Cytokine Levels in Diabetic Macular Edema Patients with Cotton-Wool Spots
复制标题
伴有棉毛斑的糖尿病黄斑水肿患者房水细胞因子水平
DOI：
10.1155/2019/8137417
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发表时间：
2019
影响因子：
4.3
通讯作者：
Jin
中科院分区：
文献类型：
--
作者：
Young;D. Jee;Jin
目的探讨糖尿病性黄斑水肿（DME）合并棉絮斑（CWS）的特点。方法根据是否有累及黄斑的CWS对80例treatment-naïve DME患者进行分类，比较各组间房水中白细胞介素- (IL-) 1β、IL-6、IL-8、IL-10、IL-17、胎盘生长因子、血管内皮生长因子（VEGF）和细胞间粘附分子(ICAM)-1的浓度、光学相干断层扫描（OCT）结果、基线特征和玻璃体内贝伐单抗反应性。结果CWS组血清ICAM-1和VEGF水平显著高于非CWS（对照组）组（p < 0.001和p = 0.006）。在确定与CWS相关因素的多元logistic回归分析中，水溶液中ICAM-1（≥0.36 ng/mL）与CWS显著相关（优势比= 13.26,p < 0.001）。基于OCT，两组之间的椭球区（EZ）破坏分布差异有统计学意义（p = 0.038）。在治疗反应性方面，两组治疗后中央亚野厚度无显著差异，但CWS组最佳矫正视力较差。结论CWS的存在伴有较高的ICAM-1水平。基于OCT， DME合并CWS患者EZ破坏更大，短期视力预后更差。
Purpose To determine the characteristics of diabetic macular edema (DME) patients with cotton-wool spots (CWS). Methods We classified 80 treatment-naïve DME patients according to whether or not they had CWS involving macula and then compared the concentrations of interleukin- (IL-) 1β, IL-6, IL-8, IL-10, IL-17, placental growth factor, vascular endothelial growth factor (VEGF), and intercellular adhesion molecule (ICAM)-1 in the aqueous humor between the groups, as well as optical coherence tomography (OCT) findings, baseline characteristics, and intravitreal bevacizumab responsiveness. Results Aqueous levels of ICAM-1 and VEGF in the group with CWS were significantly higher than those in the non-CWS (control) group (p < 0.001 and p = 0.006, respectively). In multiple logistic regression analysis to identify factors associated with CWS, the aqueous ICAM-1 (≥0.36 ng/mL) was significantly associated with CWS (odds ratio = 13.26, p < 0.001). Based on OCT, ellipsoid zone (EZ) disruption distribution was significantly different between the two groups (p = 0.038). Regarding responsiveness to treatment, although there was no significant difference in central subfield thickness between the two groups after treatments, the best-corrected visual acuity was worse in the group with CWS. Conclusions The presence of CWS was accompanied by higher levels of aqueous ICAM-1. Based on OCT, EZ disruption was greater in DME patients with CWS, and their short-term visual prognosis was poorer.
影响因子：
4.2
作者：
Maheshwary, Anjali S.;Oster, Stephen F.;Yuson, Ritchie M. S.;Cheng, Lingyun;Mojana, Francesca;Freeman, William R.
通讯作者：
Freeman, William R.