The association between percent disruption of the photoreceptor inner segment-outer segment junction and visual acuity in diabetic macular edema.
The association between percent disruption of the photoreceptor inner segment-outer segment junction and visual acuity in diabetic macular edema.
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DOI：
10.1016/j.ajo.2010.01.039
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发表时间：
2010-07
影响因子：
4.2
通讯作者：
Freeman, William R.
中科院分区：
文献类型：
--
作者：
Maheshwary, Anjali S.;Oster, Stephen F.;Yuson, Ritchie M. S.;Cheng, Lingyun;Mojana, Francesca;Freeman, William R.
目的使用频域光学相干断层扫描（SD OCT）评估糖尿病黄斑水肿患者光感受器内节/外节（IS/OS）连接的完整性，并将IS/OS连接完整性与视力之间的关系联系起来。设计回顾性、比较性、连续病例系列。方法对38例糖尿病黄斑水肿患者的62只眼睛进行SD OCT成像。对于每位患者，2 名经验丰富的观察员在蒙蔽视力的情况下测量了几个 SD OCT 变量，包括中央黄斑厚度、视网膜体积、外视网膜整体破坏程度、外视网膜破坏百分比以及既往治疗史。记录为早期治疗糖尿病视网膜病变研究字母数量的视力被用作单变量和多变量分析中的结果变量，测试测量的 SD OCT 变量作为预测因子。 结果发现 IS/OS 连接破坏百分比与视力之间存在统计学显着相关性 (P = .0312)。此外，有一个强烈的趋势表明黄斑体积和视力之间存在关系，尽管发现了临界意义（P = .07）。结论光感受器IS/OS连接的破坏是糖尿病黄斑水肿患者视力的重要预测因子。
PURPOSETo evaluate the integrity of the photoreceptor inner segment/outer segment (IS/OS) junction using spectral-domain optical coherence tomography (SD OCT) in patients with diabetic macular edema and to correlate the relationship between the integrity of the IS/OS junction and visual acuity.DESIGNRetrospective, comparative, consecutive case series.METHODSSixty-two eyes from 38 patients with diabetic macular edema underwent SD OCT imaging. For each patient, 2 experienced observers masked to visual acuity measured several SD OCT variables, including central macular thickness, retinal volume, global disruption scale of outer retina, percentage disruption of the outer retina, and history of previous treatments. Visual acuity recorded as number of Early Treatment Diabetic Retinopathy Study letters was used as the outcome variable in univariate and multivariate analysis testing the measured SD OCT variables as predictors.RESULTSA statistically significant correlation between percentage disruption of the IS/OS junction and visual acuity was found (P = .0312). Additionally, there was a strong trend suggesting a relationship between macular volume and visual acuity, although borderline significance was found (P = .07).CONCLUSIONSDisruption of the photoreceptor IS/OS junction is an important predictor of visual acuity among diabetic macular edema patients.
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影响因子：
2.6
作者：
Jahn, CE;von Schütz, KT;Kron, M
通讯作者：
Kron, M
DOI：
10.1097/iae.0b013e31802c518b
发表时间：
2007-06-01
影响因子：
3.3
作者：
Do, Diana V.;Cho, Minhee;Haller, Julia A.
通讯作者：
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DOI：
10.1097/00006982-200212000-00012
发表时间：
2002-12-01
影响因子：
3.3
作者：
Goebel, W;Kretzchmar-Gross, T
通讯作者：
Kretzchmar-Gross, T
影响因子：
4.2
作者：
Piccolino, FC;De La Longrais, RR;Manea, M
通讯作者：
Manea, M
影响因子：
13.7
作者：
Schocket, LS;Witkin, AJ;Duker, JS
通讯作者：
Duker, JS