Regenerative medicine meets mathematical modelling: developing symbiotic relationships.

Regenerative medicine meets mathematical modelling: developing symbiotic relationships.
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DOI:
10.1038/s41536-021-00134-2
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发表时间:
2021-04-12
影响因子:
7.2
通讯作者:
El Haj AJ
El Haj AJ
中科院分区:
医学1区
文献类型:
--
作者:
Waters SL;Schumacher LJ;El Haj AJ

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再生医学产品从实验室到床边的成功发展具有挑战性,需要多学科的方法。尚未完全认识到的是定量数据分析和数学建模方法支持这一过程的潜力。在这篇综述中,我们强调了在再生医学管道的各个阶段嵌入数学和计算方法的机会。我们探讨了如何利用定量数学和计算方法,以及最先进的再生医学研究,可以导致治疗,可能可以更快地转化为临床。
Successful progression from bench to bedside for regenerative medicine products is challenging and requires a multidisciplinary approach. What has not yet been fully recognised is the potential for quantitative data analysis and mathematical modelling approaches to support this process. In this review, we highlight the wealth of opportunities for embedding mathematical and computational approaches within all stages of the regenerative medicine pipeline. We explore how exploiting quantitative mathematical and computational approaches, alongside state-of-the-art regenerative medicine research, can lead to therapies that potentially can be more rapidly translated into the clinic.
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