Mechanical behavior of a soft hydrogel reinforced with three-dimensional printed microfibre scaffolds.
Mechanical behavior of a soft hydrogel reinforced with three-dimensional printed microfibre scaffolds.
复制标题
用三维印刷微纤维支架加强软水凝胶的机械行为。
DOI：
10.1038/s41598-018-19502-y
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发表时间：
2018-01-19
影响因子：
4.6
通讯作者：
Ito K
中科院分区：
文献类型：
--
作者：
Castilho M;Hochleitner G;Wilson W;van Rietbergen B;Dalton PD;Groll J;Malda J;Ito K
通过熔融静电纺丝写入（MEW）工艺获得的具有微纤维支架的增强水凝胶已经证明了开发具有与天然组织相容的机械性能的组织工程（TE）构建体的巨大前景。然而，微纤维增强水凝胶的力学性能和增强机理尚未完全了解。在这项研究中，有限元模型，实现材料性能的实验测量，被用来探索纤维-水凝胶复合材料的增强机制。首先，使用基于理想化支架几何形状的连续体有限元模型来捕获与支架抑制侧向凝胶扩张相关的加固效应，而基于压实过程中真实的结构几何形状的显微CT图像的第二个显微有限元模型捕获了通过支架互连的载荷转移效应。结果表明，在更高的支架体积分数的增强机制是由纤维支架互连的承载能力，这是远远高于预期的基础上测试支架单独，因为水凝胶提供抗屈曲的支架。我们建议，在这项工作中提出的理论理解将有助于设计更有效的复合材料结构，在广泛的TE条件下具有潜在的应用。
Reinforcing hydrogels with micro-fibre scaffolds obtained by a Melt-Electrospinning Writing (MEW) process has demonstrated great promise for developing tissue engineered (TE) constructs with mechanical properties compatible to native tissues. However, the mechanical performance and reinforcement mechanism of the micro-fibre reinforced hydrogels is not yet fully understood. In this study, FE models, implementing material properties measured experimentally, were used to explore the reinforcement mechanism of fibre-hydrogel composites. First, a continuum FE model based on idealized scaffold geometry was used to capture reinforcement effects related to the suppression of lateral gel expansion by the scaffold, while a second micro-FE model based on micro-CT images of the real construct geometry during compaction captured the effects of load transfer through the scaffold interconnections. Results demonstrate that the reinforcement mechanism at higher scaffold volume fractions was dominated by the load carrying-ability of the fibre scaffold interconnections, which was much higher than expected based on testing scaffolds alone because the hydrogel provides resistance against buckling of the scaffold. We propose that the theoretical understanding presented in this work will assist the design of more effective composite constructs with potential applications in a wide range of TE conditions.
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DOI：
10.1016/j.msec.2015.09.102
发表时间：
2016-02-01
影响因子：
7.9
作者：
Baker, Stephen R.;Banerjee, Soham;Guthold, Martin
通讯作者：
Guthold, Martin
影响因子：
3.5
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影响因子：
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作者：
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通讯作者：
Elisseeff J
影响因子：
10
作者：
Castilho M;Feyen D;Flandes-Iparraguirre M;Hochleitner G;Groll J;Doevendans PAF;Vermonden T;Ito K;Sluijter JPG;Malda J
通讯作者：
Malda J