Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis.
Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis.
复制标题
溃疡性结肠炎患者粪便微生物群移植反应的供体和受体预测生物标志物的系统评价。
DOI：
10.1016/j.ebiom.2022.104088
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发表时间：
2022-07
期刊：
影响因子：
11.1
通讯作者：
Quraishi, Mohammed Nabil
中科院分区：
文献类型：
--
作者：
Rees, Nia Paddison;Shaheen, Walaa;Quince, Christopher;Tselepis, Chris;Horniblow, Richard D.;Sharma, Naveen;Beggs, Andrew D.;Iqbal, Tariq H.;Quraishi, Mohammed Nabil
粪便微生物群移植（FMT）先前已被探索作为溃疡性结肠炎（UC）的治疗方法，然而，预测和/或与临床反应相关的生物标志物尚未明确定义。本系统综述的目的是确定供体和受体对UC患者FMT反应的临床、微生物和代谢组学预测生物标志物。系统检索了UC中FMT研究的相关文献。研究了微生物多样性、分类学变化、代谢变化、供体和受体微生物群关系和基线预测因子的数据。本系统综述共筛选2852项研究，纳入25篇论文。FMT后，应答者的α多样性随着梭菌群（目）和拟杆菌属丰度的增加而增加。代谢组学分析显示，短链脂肪酸（SCFA）的产生是FMT成功的标志。具有较高的微生物α多样性和属于某些拟杆菌和梭菌群的类群丰度的供体或FMT批次与FMT的临床反应相关。UC患者反应的基线临床预测指标包括年龄更年轻、病情较轻、病程可能更短。应答时的基线受体微生物预测因子包括较高的粪便物种丰富度、较高的念珠菌丰度和供体微生物谱相似性。fmt后肠道微生物群特征的明显变化表明，某些基线特征以及特定的微生物和代谢组学改变可能使患者倾向于成功的治疗结果。在未来的临床研究中，应该探索以生物标志物为主导的FMT精准医学方法。没有具体的资金需要申报。
Faecal microbiota transplantation (FMT) has previously been explored as a treatment for ulcerative colitis (UC) however, biomarkers that predict and / or are associated with clinical response are poorly defined. The aim of this systematic review was to identify donor and recipient clinical, microbial and metabolomic predictive biomarkers of response to FMT in UC. A systematic search of the relevant literature of studies exploring FMT in UC was conducted. Data on microbial diversity, taxonomic changes, metabolic changes, donor and recipient microbiota relationship and baseline predictors was examined. 2852 studies were screened, and 25 papers were included in this systematic review. Following FMT, alpha diversity was seen to increase in responders along with increases in the abundance of Clostridiales clusters (order) and Bacteroides genus. Metabolomic analysis revealed short chain fatty acid (SCFA) production as a marker of FMT success. Donors or FMT batches with higher microbial alpha diversity and a greater abundance of taxa belonging to certain Bacteroides and Clostridia clusters were associated with clinical response to FMT. Baseline clinical predictors of response in patients with UC included younger age, less severe disease and possibly shorter disease duration. Baseline recipient microbial predictors at response consisted of higher faecal species richness, greater abundance of Candida and donor microbial profile similarity. Distinct changes in gut microbiota profiles post-FMT indicate that certain baseline characteristics along with specific microbial and metabolomic alterations may predispose patients towards a successful therapeutic outcome. Opportunities towards a biomarker led precision medicine approach with FMT should be explored in future clinical studies. There no specific funding to declare.
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影响因子：
5.9
作者：
Merra G;Noce A;Marrone G;Cintoni M;Tarsitano MG;Capacci A;De Lorenzo A
通讯作者：
De Lorenzo A
影响因子：
7.4
作者：
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影响因子：
4
作者：
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通讯作者：
Loeb M
影响因子：
29.4
作者：
Moayyedi, Paul;Surette, Michael G.;Lee, Christine H.
通讯作者：
Lee, Christine H.
影响因子：
7.6
作者：
Kump P;Wurm P;Gröchenig HP;Wenzl H;Petritsch W;Halwachs B;Wagner M;Stadlbauer V;Eherer A;Hoffmann KM;Deutschmann A;Reicht G;Reiter L;Slawitsch P;Gorkiewicz G;Högenauer C
通讯作者：
Högenauer C