Residue Analysis and Assessment of the Risk of Dietary Exposure to Domoic Acid in Shellfish from the Coastal Areas of China.
Residue Analysis and Assessment of the Risk of Dietary Exposure to Domoic Acid in Shellfish from the Coastal Areas of China.
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DOI：
10.3390/toxins14120862
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发表时间：
2022-12-08
期刊：
影响因子：
4.2
通讯作者：
Tan Z
中科院分区：
文献类型：
--
作者：
Zheng G;Wu H;Che H;Li X;Zhang Z;Peng J;Guo M;Tan Z
中国海域有害藻华已造成贝类中软骨藻酸(DA)的严重污染。尽管贝类在膳食中暴露于DA的风险特别大，但在中国沿海水域还没有系统的DA风险评估。从2020年3月至11月，共采集了451个贝类样本。用液相色谱-串联质谱法检测了DA及其4种异构体的存在。研究了DA发生的时空分布及其潜在的健康风险。贝类样品中检出DA 198份(43.90%)，最高检出量为942.86μg/kg。所有14种贝类均录得DA，其中太平洋牡蛎(Crassostrea Gias)的平均DA含量最高(82.36μg/kg)。贝类中DA的浓度具有明显的时空变化，秋季显著高于夏季和春季(p<；0.01)，广东和福建两省的DA含量最高。四种DA异构体的检出率和最高浓度均较低。虽然9月份来自广东省的大头蟹显示出最高的DA污染水平，但对人类消费者的风险很低。这项研究提高了我们对贝类接触DA-残留物的潜在风险的理解。
Harmful algal blooms in Chinese waters have caused serious domoic acid (DA) contamination in shellfish. Although shellfish are at particular risk of dietary exposure to DA, there have been no systematic DA risk assessments in Chinese coastal waters. A total of 451 shellfish samples were collected from March to November 2020. The presence of DA and four of its isomers were detected using liquid chromatography–tandem mass spectrometry. The spatial-temporal distribution of DA occurrence and its potential health risks were examined. DA was detected in 198 shellfish samples (43.90%), with a maximum level of 942.86 μg/kg. DA was recorded in all 14 shellfish species tested and Pacific oysters (Crassostrea gigas) showed the highest average DA concentration (82.36 μg/kg). The DA concentrations in shellfish showed distinct spatial-temporal variations, with significantly higher levels of occurrence in autumn than in summer and spring (p < 0.01), and particularly high occurrence in Guangdong and Fujian Provinces. The detection rates and maximum concentrations of the four DA isomers were low. While C. gigas from Guangdong Province in September showed the highest levels of DA contamination, the risk to human consumers was low. This study improves our understanding of the potential risk of shellfish exposure to DA-residues.
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