Quantitative accuracy of attenuation correction in the Philips Ingenuity TF whole-body PET/MR system: a direct comparison with transmission-based attenuation correction.
Quantitative accuracy of attenuation correction in the Philips Ingenuity TF whole-body PET/MR system: a direct comparison with transmission-based attenuation correction.
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DOI：
10.1007/s10334-012-0328-5
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发表时间：
2013-02
影响因子：
2.3
通讯作者：
van den Hoff, Joerg
中科院分区：
文献类型：
--
作者：
Schramm, Georg;Langner, Jens;Hofheinz, Frank;Petr, Jan;Beuthien-Baumann, Bettina;Platzek, Ivan;Steinbach, Joerg;Kotzerke, Joerg;van den Hoff, Joerg
基于MR的衰减校正(MRAC)在飞利浦Invenity TF全身PET/MR中定量准确性的评价在13例患者中，使用两种不同的衰减校正方法重建了PET/MR的PET发射数据。在第一次重建中，使用了供应商提供的标准MRAC。在第二次重建中，使用了与西门子ECAT Exact HR+PET扫描仪(TRAC)共同记录的基于传输的衰减图，该图来自第二次前一次调查。比较两种衰减图在MRAC过程中分割伪影的出现情况。在两个重建的数据集之间比较多个VOI(肝脏、小脑、躯干不同位置的热灶结构)的标准摄取值(SUV)。此外，对肺和躯干的两个数据集进行了体素强度相关分析。MRAC和TRAC的VOI平均SUV差值(相对差值，平均标准差)为：小脑(+12±9.6)%，肝脏(−4±9.9)%，热灶结构(−2±10.11)%。肺和躯干体素相关的拟合斜率分别为0.87±0.17和0.95±0.10，平均校正R2分别为0.96和0.98。这些数字包括两个由于MR图像中的伪影而导致部分错误的肺分割的实例。在飞利浦Invenity PET/MR上实施的基于MR的衰减校正提供了合理的定量精度。平均而言，整个主干与基于TRAC的结果的偏差很小(约为10%或更低)，但由于分段质量的个体间差异，可能会发生超过20%的偏差。未来分割质量的提高将有助于进一步提高量化精度，降低主题间的变异性。
Evaluation of the quantitative accuracy of MR-based attenuation correction (MRAC) in the Philips Ingenuity TF whole-body PET/MR. In 13 patients, PET emission data from the PET/MR were reconstructed using two different methods for attenuation correction. In the first reconstruction, the vendor-provided standard MRAC was used. In the second reconstruction, a coregistered transmission-based attenuation map from a second immediately preceding investigation with a stand-alone Siemens ECAT EXACT HR+ PET scanner was used (TRAC). The two attenuation maps were compared regarding occurrence of segmentation artifacts in the MRAC procedure. Standard uptake values (SUVs) of multiple VOIs (liver, cerebellum, hot focal structures at various locations in the trunk) were compared between both reconstructed data sets. Furthermore, a voxel-wise intensity correlation analysis of both data sets in the lung and trunk was performed. VOI averaged SUV differences between MRAC and TRAC were as follows (relative differences, mean ± standard deviation): (+12 ± 6) % cerebellum, (−4 ± 9) % liver, (−2 ± 11) % hot focal structures. The fitted slopes of the voxel-wise correlations in the lung and trunk were 0.87 ± 0.17 and 0.95 ± 0.10 with averaged adjusted R 2 values of 0.96 and 0.98, respectively. These figures include two instances with partially erroneous lung segmentation due to artifacts in the underlying MR images. The MR-based attenuation correction implemented on the Philips Ingenuity PET/MR provides reasonable quantitative accuracy. On average, deviations from TRAC-based results are small (on the order of 10 % or below) across the trunk, but due to interindividual variability of the segmentation quality, deviations of more than 20 % can occur. Future improvement of the segmentation quality would help to increase the quantitation accuracy further and to reduce the inter-subject variability.
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影响因子：
3.5
作者：
Zaidi H;Ojha N;Morich M;Griesmer J;Hu Z;Maniawski P;Ratib O;Izquierdo-Garcia D;Fayad ZA;Shao L
通讯作者：
Shao L
影响因子：
9.3
作者：
Hofmann, Matthias;Steinke, Florian;Pichler, Bernd J.
通讯作者：
Pichler, Bernd J.
影响因子：
9.3
作者：
Martinez-Moeller, Axel;Souvatzoglou, Michael;Nekolla, Stephan G.
通讯作者：
Nekolla, Stephan G.
DOI：
10.1007/s00259-002-0796-3
发表时间：
2002-07-01
影响因子：
9.1
作者：
Burger, C;Goerres, G;von Schulthess, GK
通讯作者：
von Schulthess, GK
影响因子：
9.3
作者：
Delso, Gaspar;Fuerst, Sebastian;Ziegler, Sibylle I.
通讯作者：
Ziegler, Sibylle I.