Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system.
Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system.
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DOI：
10.1088/0031-9155/56/10/013
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发表时间：
2011-05-21
影响因子：
3.5
通讯作者：
Shao L
中科院分区：
文献类型：
--
作者：
Zaidi H;Ojha N;Morich M;Griesmer J;Hu Z;Maniawski P;Ratib O;Izquierdo-Garcia D;Fayad ZA;Shao L
独创性的TFPET-MRI是最新发布的全身混合PET-MR成像系统，配备了飞利浦Time-of-Flight Gemini TFPET和Achieva 3T X系列MRI系统。与PET-CT相比，对正电子发射断层扫描(PET)机架进行了改进，以避免相互系统干扰，并提供与独立系统相当的不打折扣的性能。重新设计了PET门架，为光电倍增管(PMT)引入了磁屏蔽。MR系统对电磁噪声的严格要求要求拆除放置在PET-MR设备机房中的PET龙门电子设备。我们报告了PET扫描仪的标准NEMA测量结果。根据NEMA标准NU2-2007手册中的描述，在日内瓦大学医院进行了PET成像和性能测量。用NEMA圆柱体(直径20 cm)对两个较大的圆柱体(直径27 cm和35 cm)重复测量散射分数(SF)和噪声当量计数率(NECR)，这两个圆柱体更好地代表了中等和重度患者。使用NEMA/IEC躯干体模对图像质量进行总体评价。中心附近的横向和轴向分辨率为4.7 mm。PET-MR系统的时间分辨率和能量分辨率分别为525ps和12%。结果与PET-CT系统相当，表明需要对PET系统进行设计修改以消除磁场对PMT的有害影响的影响可以忽略不计。该扫描仪的绝对灵敏度为7.0cps kBq−1，SF为26%。用三个不同直径的圆柱体进行NECR测量，用IEC体模进行图像质量测量，结果很好。独创性的TFPET-MRI代表了第一个商业化的全身混合型PET-MRI系统。在体模和患者研究中，PET子系统的性能与Gemini TF PET-CT系统相当。可以设想，在不久的将来，混合PET-MRI的优势将更加明显。
The Ingenuity TF PET–MRI is a newly released whole-body hybrid PET–MR imaging system with a Philips time-of-flight GEMINI TF PET and Achieva 3T X-series MRI system. Compared to PET–CT, modifications to the positron emission tomography (PET) gantry were made to avoid mutual system interference and deliver uncompromising performance which is equivalent to the standalone systems. The PET gantry was redesigned to introduce magnetic shielding for the photomultiplier tubes (PMTs). Stringent electromagnetic noise requirements of the MR system necessitated the removal of PET gantry electronics to be housed in the PET–MR equipment room. We report the standard NEMA measurements for the PET scanner. PET imaging and performance measurements were done at Geneva University Hospital as described in the NEMA Standards NU2-2007 manual. The scatter fraction (SF) and noise equivalent count rate (NECR) measurements with the NEMA cylinder (20 cm diameter) were repeated for two larger cylinders (27 cm and 35 cm diameter), which better represent average and heavy patients. A NEMA/IEC torso phantom was used for overall assessment of image quality. The transverse and axial resolution near the center was 4.7 mm. Timing and energy resolution of the PET–MR system were measured to be 525 ps and 12%, respectively. The results were comparable to PET–CT systems demonstrating that the effect of design modifications required on the PET system to remove the harmful effect of the magnetic field on the PMTs was negligible. The absolute sensitivity of this scanner was 7.0 cps kBq−1, whereas SF was 26%. NECR measurements performed with cylinders having three different diameters, and image quality measurements performed with IEC phantom yielded excellent results. The Ingenuity TF PET–MRI represents the first commercial whole-body hybrid PET–MRI system. The performance of the PET subsystem was comparable to the GEMINI TF PET–CT system using phantom and patient studies. It is conceived that advantages of hybrid PET–MRI will become more evident in the near future.
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影响因子：
82.9
作者：
Judenhofer, Martin S.;Wehrl, Hans F.;Pichler, Bernd J.
通讯作者：
Pichler, Bernd J.
影响因子：
1.8
作者：
Matej, S;Lewitt, RM
通讯作者：
Lewitt, RM
影响因子：
19.7
作者：
Judenhofer, Martin S.;Catana, Ciprian;Pichler, Bernd J.
通讯作者：
Pichler, Bernd J.
影响因子：
19.7
作者：
Schlemmer, Heinz-Peter W.;Pichler, Bernd J.;Claussen, Claus D.
通讯作者：
Claussen, Claus D.
DOI：
10.1007/s00259-009-1078-0
发表时间：
2009-03-01
影响因子：
9.1
作者：
Wehrl, Hans F.;Judenhofer, Martin S.;Pichler, Bernd J.
通讯作者：
Pichler, Bernd J.