Angiotensin-converting enzyme in innate and adaptive immunity.
Angiotensin-converting enzyme in innate and adaptive immunity.
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DOI：
10.1038/nrneph.2018.15
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Shen XZ
中科院分区：
文献类型：
--
作者：
Bernstein KE;Khan Z;Giani JF;Cao DY;Bernstein EA;Shen XZ
血管紧张素转换酶（ACE）--一种具有两个催化结构域的锌依赖性二羧肽酶--通过将血管紧张素I转化为血管紧张素II在血压调节中发挥重要作用。然而，ACE切割除了血管紧张素I之外的许多肽，从而影响多种生理功能，包括肾脏发育和男性生殖。此外，ACE通过调节巨噬细胞和中性粒细胞功能在先天性和适应性反应中发挥作用-当这些细胞过度表达ACE时，这种作用被放大。过表达ACE的巨噬细胞对肿瘤和感染更有效。过表达ACE的中性粒细胞产生的超氧化物增加，这增加了它们杀死细菌的能力。这些作用是由于ACE活性增加，但不依赖于血管紧张素II。ACE还影响主要组织相容性复合体（MHC）I类和MHC II类肽的展示，可能是通过酶促修剪这些肽。了解ACE的表达和活性如何影响骨髓细胞可能为治疗操作带来巨大希望，包括感染和恶性肿瘤的治疗。
Angiotensin-converting enzyme (ACE) — a zinc-dependent dicarboxypeptidase with two catalytic domains — plays a major part in blood pressure regulation by converting angiotensin I to angiotensin II. However, ACE cleaves many peptides besides angiotensin I and thereby affects diverse physiological functions, including renal development and male reproduction. In addition, ACE has a role in both innate and adaptive responses by modulating macrophage and neutrophil function — effects that are magnified when these cells overexpress ACE. Macrophages that overexpress ACE are more effective against tumours and infections. Neutrophils that overexpress ACE have an increased production of superoxide, which increases their ability to kill bacteria. These effects are due to increased ACE activity but are independent of angiotensin II. ACE also affects the display of major histocompatibility complex (MHC) class I and MHC class II peptides, potentially by enzymatically trimming these peptides. Understanding how ACE expression and activity affect myeloid cells may hold great promise for therapeutic manipulation, including the treatment of both infection and malignancy.
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影响因子：
2.6
作者：
Danilov, SM;Sadovnikova, E;Adema, GJ
通讯作者：
Adema, GJ
影响因子：
3.1
作者：
Bouley, DM;Ghori, N;Ramakrishnan, L
通讯作者：
Ramakrishnan, L
巨噬细胞上皮重编程是分枝杆菌肉芽肿的基础并促进感染。
影响因子：
32.4
作者：
Cronan MR;Beerman RW;Rosenberg AF;Saelens JW;Johnson MG;Oehlers SH;Sisk DM;Jurcic Smith KL;Medvitz NA;Miller SE;Trinh LA;Fraser SE;Madden JF;Turner J;Stout JE;Lee S;Tobin DM
通讯作者：
Tobin DM
影响因子：
3.7
作者：
Barauna, Valerio Garrone;Gastalho Campos, Luciene Cristina;Krieger, Jose Eduardo
通讯作者：
Krieger, Jose Eduardo
影响因子：
15.9
作者：
Bernstein, Kenneth E.;Koronyo, Yosef;Koronyo-Hamaoui, Maya
通讯作者：
Koronyo-Hamaoui, Maya